A novel multiparametric imaging approach to acute myocarditis using T2-mapping and CMR feature tracking.
A novel multiparametric imaging approach to acute myocarditis using T2-mapping and CMR feature tracking.
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DOI：
10.1186/s12968-017-0387-x
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发表时间：
2017-09-21
期刊：
影响因子：
--
通讯作者：
Bunck AC
中科院分区：
文献类型：
--
作者：
Baeßler B;Treutlein M;Schaarschmidt F;Stehning C;Schnackenburg B;Michels G;Maintz D;Bunck AC
本研究的目的是评价一种新的心血管磁共振（CMR）的多参数成像方法在疑似心肌炎的诊断潜力，并将其与传统的露易丝湖标准（LLC）进行比较。回顾性分析67例疑似急性心肌炎患者的CMR资料。17名年龄和性别匹配的健康受试者作为对照。T2标测数据采用顺磁自旋回波T2标测序列在短轴方向采集。根据16节段AHA模型对T2图进行分段，并记录节段T2值和像素标准差（SD）。然后，计算每个受试者的参数maxT2（最高节段T2值）和madSD（像素SD的平均绝对偏差（MAD））。使用专用的特征跟踪算法分析三个长轴和覆盖左右心室的短轴视图堆栈中的电影序列。与包含单一成像参数的任何模型或LLC（AUC 0.79）相比，包含madSD和LV全局周向应变（GCSLV）的多参数成像模型在接受者工作曲线分析中的诊断性能最高（曲线下面积[AUC] 0.84）。将晚期钆增强（LGE）添加到模型中导致进一步提高诊断性能（AUC 0.93），并产生97%的最高诊断灵敏度和77%的特异性。当与任何单独的成像参数和LLC相比时，包括新的T2映射导出的参数madSD、特征跟踪导出的应变参数GCSLV和LGE的多参数CMR成像模型在疑似急性心肌炎中产生上级诊断灵敏度。
The aim of this study was to evaluate the diagnostic potential of a novel cardiovascular magnetic resonance (CMR) based multiparametric imaging approach in suspected myocarditis and to compare it to traditional Lake Louise criteria (LLC). CMR data from 67 patients with suspected acute myocarditis were retrospectively analyzed. Seventeen age- and gender-matched healthy subjects served as control. T2-mapping data were acquired using a Gradient-Spin-Echo T2-mapping sequence in short-axis orientation. T2-maps were segmented according to the 16-segments AHA-model and segmental T2 values and pixel-standard deviation (SD) were recorded. Afterwards, the parameters maxT2 (the highest segmental T2 value) and madSD (the mean absolute deviation (MAD) of the pixel-SDs) were calculated for each subject. Cine sequences in three long axes and a stack of short-axis views covering the left and right ventricle were analyzed using a dedicated feature tracking algorithm. A multiparametric imaging model containing madSD and LV global circumferential strain (GCSLV) resulted in the highest diagnostic performance in receiver operating curve analyses (area under the curve [AUC] 0.84) when compared to any model containing a single imaging parameter or to LLC (AUC 0.79). Adding late gadolinium enhancement (LGE) to the model resulted in a further increased diagnostic performance (AUC 0.93) and yielded the highest diagnostic sensitivity of 97% and specificity of 77%. A multiparametric CMR imaging model including the novel T2-mapping derived parameter madSD, the feature tracking derived strain parameter GCSLV and LGE yields superior diagnostic sensitivity in suspected acute myocarditis when compared to any imaging parameter alone and to LLC.
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DOI：
10.1016/0735-1097(94)90424-3
发表时间：
1994-02-01
影响因子：
24
作者：
CERQUEIRA, MD;VERANI, MS;WILLIAMS, KA
通讯作者：
WILLIAMS, KA
影响因子：
24
作者：
Abdel-Aty, H;Boyé, P;Schulz-Menger, J
通讯作者：
Schulz-Menger, J
影响因子：
7.5
作者：
Friedrich, Matthias G.;Marcotte, Francois
通讯作者：
Marcotte, Francois
影响因子：
6.4
作者：
Giri, Shivraman;Chung, Yiu-Cho;Simonetti, Orlando P.
通讯作者：
Simonetti, Orlando P.
影响因子：
14
作者：
Ferreira, Vanessa M.;Piechnik, Stefan K.;Neubauer, Stefan
通讯作者：
Neubauer, Stefan