Frequent gene amplification predicts poor prognosis in gastric cancer.
Frequent gene amplification predicts poor prognosis in gastric cancer.
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DOI：
10.3390/ijms13044714
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发表时间：
2012
影响因子：
5.6
通讯作者：
Ji M
中科院分区：
文献类型：
--
作者：
Shi J;Yao D;Liu W;Wang N;Lv H;He N;Shi B;Hou P;Ji M
胃癌是世界上最常见的恶性肿瘤之一。然而，导致这种疾病的基因改变在很大程度上是未知的。基因扩增是最常见的基因改变之一，被认为在胃癌的发生发展中起着重要作用。在本研究中，我们利用实时定量PCR方法从30个候选基因中鉴定出ERBB4、C-MET和CD44这3个扩增频率较高的基因，并进一步探讨它们与胃癌队列临床病理特征和低生存率的关系。我们的数据显示，这些基因的扩增与某些临床病理特征显著相关，特别是肿瘤分化和癌症相关死亡。更重要的是，这些基因的扩增与较差的生存率显著相关，提示这些扩增的基因可能是胃癌不良预后的重要预测因子和潜在的治疗靶点。因此，靶向这些基因可能为胃癌的治疗提供新的可能性。
Gastric cancer is one of the most common malignancies worldwide. However, genetic alterations leading to this disease are largely unknown. Gene amplification is one of the most frequent genetic alterations, which is believed to play a major role in the development and progression of gastric cancer. In the present study, we identified three frequently amplified genes from 30 candidate genes using real-time quantitative PCR method, including ERBB4, C-MET and CD44, and further explored their association with clinicopathological characteristics and poor survival in a cohort of gastric cancers. Our data showed amplification of these genes was significantly associated with certain clinicopathological characteristics, particularly tumor differentiation and cancer-related death. More importantly, amplification of these genes was significantly related to worse survival, suggesting that these amplified genes may be significant predictors of poor prognosis and potential therapeutic targets in gastric cancer. Targeting these genes may thus provide new possibilities in the treatment of gastric cancer.
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DOI：
10.1007/s00428-009-0814-y
发表时间：
2009-09
期刊：
Virchows Archiv : an international journal of pathology
影响因子：
--
作者：
Buffart TE;van Grieken NC;Tijssen M;Coffa J;Ylstra B;Grabsch HI;van de Velde CJ;Carvalho B;Meijer GA
通讯作者：
Meijer GA
DOI：
10.1073/pnas.0508776103
发表时间：
2006-02-14
影响因子：
11.1
作者：
Smolen, GA;Sordella, R;Haber, DA
通讯作者：
Haber, DA
影响因子：
11.5
作者：
Hou, Peng;Liu, Dingxie;Xing, Mingzhao
通讯作者：
Xing, Mingzhao
影响因子：
4.2
作者：
Lee, Jeeyun;Seo, Jin Won;Park, Joon Oh
通讯作者：
Park, Joon Oh
影响因子：
4.9
作者：
Sierra, J Rafael;Tsao, Ming-Sound
通讯作者：
Tsao, Ming-Sound