Hemodynamic change in patients with hypertrophic obstructive cardiomyopathy before and after alcohol septal ablation using 4D flow magnetic resonance imaging: a retrospective observational study.
Hemodynamic change in patients with hypertrophic obstructive cardiomyopathy before and after alcohol septal ablation using 4D flow magnetic resonance imaging: a retrospective observational study.
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使用4D流量磁共振成像在酒精中间消融前后，肥厚性阻塞性心肌病患者的血液动力学变化：回顾性观察性研究。
DOI：
10.1186/s12872-021-02003-8
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发表时间：
2021-04-20
影响因子：
2.1
通讯作者：
Maekawa Y
中科院分区：
文献类型：
--
作者：
Suwa K;Akita K;Iguchi K;Ushio T;Maekawa Y
阐明了肥厚型梗阻性心肌病 (HOCM) 患者酒精室间隔消融 (ASA) 前后左心室 (LV) 和升主动脉 (AAO) 的血流动力学。我们的目的是评估 ASA 前后通过四维 (4D) 血流磁共振成像 (MRI) 评估的 AAO 和左心室内血流模式变化，并阐明 4D 血流 MRI 衍生的血流动力学特征与药物难治性 HOCM 患者的峰值压力梯度 (PPG) 之间的关联。在这项回顾性观察研究中，11 名 HOCM 患者在 ASA 之前和之后一周接受了 4D 血流 MRI。 4D 血流 MRI 包括使用流线图像进行血流可视化和量化。分析了 AAO 中涡旋和螺旋的综合得分。对 AAO 涡流或螺旋流的持续时间和相位计数以及左心室内前涡流的大小进行量化。还分析了左室流出道血流动力学变化与静息 PPG 之间的相关性。我们使用配对t检验进行ASA前后的比较，并使用Pearson相关系数进行分析。 ASA 后 AAO 中涡流和/或螺旋流发生率的综合评分显着低于 ASA 前（1.45 ± 0.52 vs. 1.09 ± 0.30，p = 0.046）。 ASA 后，AAO 中涡流或螺旋流的持续时间（744 ± 291 毫秒 vs. 467 ± 258 毫秒，p < 0.001）和相数（14.8 ± 4.4 相 vs. 10.5 ± 5.8 相，p < 0.001）显着减少。 ASA术后左室前涡面积明显大于ASA前（1628±420 mm2 vs. 2974±539 mm2，p=±0.009）。 ASA 之前和之后一周的 AAO 涡旋或螺旋的 δ 相计数与 ASA 之前和之后一周的 δ PPG 显着相关（R = 0.79，p = 0.004），并且与 ASA 之前和之后 6 个月的 δ PPG 显着相关（R = 0.83，p = 0.002）。 ASA后观察到AAO中较低的涡流或螺旋流和LV中较大的舒张期涡流，这表明有可能检测HOCM中异常血流动力学的变化。在线版本包含可在 10.1186/s12872-021-02003-8 获取的补充材料。
The hemodynamics in the left ventricle (LV) and the ascending aorta (AAO) before and after alcohol septal ablation (ASA) in patients with hypertrophic obstructive cardiomyopathy (HOCM) is elucidated. Our objective was to evaluate the pattern changes in AAO and intra-LV flow assessed by four-dimensional (4D) flow magnetic resonance imaging (MRI) before and after ASA and to clarify the association between 4D flow MRI-derived hemodynamic characteristics and the peak pressure gradient (PPG) in patients with drug-refractory HOCM. In this retrospective observational study, 11 patients with HOCM underwent 4D flow MRI before and a week after ASA. The 4D flow MRI included blood flow visualization and quantification using streamline images. The combined score of vortex and helix in AAO was analyzed. The duration and phase count of the AAO vortex or helix flow and the size of the intra-LV anterior vortex were quantified. The correlation between the changes in hemodynamics and the resting PPG at LV outflow tract was also analyzed. We used the paired t-test for the comparison between before and after ASA and the Pearson’s correlation coefficient for the analysis. The combined score for the incidence of vortex and/or helix flow in AAO after ASA was significantly lower than that before ASA (1.45 ± 0.52 vs. 1.09 ± 0.30, p = 0.046). The duration (744 ± 291 ms vs. 467 ± 258 ms, p < 0.001) and phase count (14.8 ± 4.4 phases vs. 10.5 ± 5.8 phases, p < 0.001) of the vortex or helix flow in AAO were significantly decreased after ASA. The LV anterior vortex area after ASA was significantly larger than that before ASA (1628 ± 420 mm2 vs. 2974 ± 539 mm2, p = 0.009). The delta phase count of the AAO vortex or helix before and a week after ASA was significantly correlated with delta PPG before and a week after ASA (R = 0.79, p = 0.004) and with delta PPG before and 6 months after ASA (R = 0.83, p = 0.002). Lower vortex or helix flow in AAO and larger diastolic vortex flow in LV were observed after ASA, which suggests the possibility to detect the changes of aberrant hemodynamics in HOCM. The online version contains supplementary material available at 10.1186/s12872-021-02003-8.
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影响因子：
39.3
作者：
Elliott, Perry M.;Anastasakis, Aris;Watkins, Hugh
通讯作者：
Watkins, Hugh
影响因子：
3.3
作者：
Veselka, Josef;Duchohova, Radka;Cervinka, Pavel
通讯作者：
Cervinka, Pavel
DOI：
10.1161/circimaging.115.004038
发表时间：
2016-03
期刊：
Circulation. Cardiovascular imaging
影响因子：
--
作者：
von Knobelsdorff-Brenkenhoff F;Karunaharamoorthy A;Trauzeddel RF;Barker AJ;Blaszczyk E;Markl M;Schulz-Menger J
通讯作者：
Schulz-Menger J
DOI：
10.1186/1532-429x-14-84
发表时间：
2012-12-13
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Bürk J;Blanke P;Stankovic Z;Barker A;Russe M;Geiger J;Frydrychowicz A;Langer M;Markl M
通讯作者：
Markl M
影响因子：
2.7
作者：
Akita K;Tsuruta H;Yuasa S;Murata M;Fukuda K;Maekawa Y
通讯作者：
Maekawa Y