Analysis of vascular inflammation against bioresorbable Zn-Ag based alloys.
Analysis of vascular inflammation against bioresorbable Zn-Ag based alloys.
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DOI：
10.1021/acsabm.0c00740
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发表时间：
2020-10-19
影响因子：
4.7
通讯作者：
Goldman J
中科院分区：
文献类型：
--
作者：
Oliver AA;Guillory RJ 2nd;Flom KL;Morath LM;Kolesar TM;Mostaed E;Sikora-Jasinska M;Drelich JW;Goldman J
锌（Zn）由于其令人满意的腐蚀行为和优异的生物相容性而成为一种有前途的生物可吸收支架材料。然而，对于承载植入物应用，需要合金化来提高其机械性能，因为纯锌的强度较差。不幸的是，相对于纯锌，炎症的增加是锌合金常见的副作用。因此，开发一种能够同时改善机械性能和抑制炎症反应的锌基合金是一个巨大的挑战。在这里，与参考材料相比，对生物可吸收、生物相容性锌银基五元合金进行了体内综合评估。炎症和平滑肌细胞反应被表征并与新内膜生长指标相关。我们发现，相对于参考材料，五元合金的植入与炎症活动的显着改善相关。此外，我们发现炎症（而非平滑肌细胞增生）与锌合金的新内膜生长显着相关。结果表明，炎症是锌基合金新内膜生长的主要驱动力，五元 Zn-Ag-Mn-Zr-Cu 合金可以赋予动脉植入物抗炎特性。
Zinc (Zn) has emerged as a promising bioresorbable stent material due to its satisfactory corrosion behavior and excellent biocompatibility. However, for load bearing implant applications, alloying is required to boost its mechanical properties as pure Zn exhibits poor strength. Unfortunately, an increase in inflammation relative to pure Zn is a commonly observed side-effect of Zn alloys. Consequently, the development of a Zn-based alloy that can simultaneously feature improved mechanical properties and suppress inflammatory responses is a big challenge. Here, a bioresorbable, biocompatible Zn-Ag-based quinary alloy was comprehensively evaluated in vivo, in comparison to reference materials. The inflammatory and smooth muscle cellular response was characterized and correlated to metrics of neointimal growth. We found that implantation of the quinary alloy was associated with significantly improved inflammatory activities relative to the reference materials. Additionally, we found that inflammation, but not smooth muscle cell hyperplasia, significantly correlates to neointimal growth for Zn alloys. The results suggest that inflammation is the main driver of neointimal growth for Zn-based alloys and that the quinary Zn-Ag-Mn-Zr-Cu alloy may impart inflammation-resistance properties to arterial implants.
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影响因子：
2.1
作者：
Ghasemi A;Zahediasl S
通讯作者：
Zahediasl S
DOI：
10.1039/p29960000481
发表时间：
1996-04-01
期刊：
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2
影响因子：
--
作者：
Dicks, AP;Swift, HR;Cox, BG
通讯作者：
Cox, BG
影响因子：
9.5
作者：
Guillory, Roger J., II;Sikora-Jasinska, Malgorzata;Goldman, Jeremy
通讯作者：
Goldman, Jeremy
DOI：
10.1073/pnas.88.11.4651
发表时间：
1991-06-01
影响因子：
11.1
作者：
KUBES, P;SUZUKI, M;GRANGER, DN
通讯作者：
GRANGER, DN
DOI：
10.1016/j.msec.2015.07.022
发表时间：
2015-11-01
期刊：
Materials science & engineering. C, Materials for biological applications
影响因子：
--
作者：
Bowen PK;Guillory RJ 2nd;Shearier ER;Seitz JM;Drelich J;Bocks M;Zhao F;Goldman J
通讯作者：
Goldman J