Pyrenebutyrate-mediated delivery of quantum dots across the plasma membrane of living cells.
Pyrenebutyrate-mediated delivery of quantum dots across the plasma membrane of living cells.
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吡啶并培养皿介导的量子点在活细胞的质膜上递送。
DOI：
10.1021/jp809956w
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发表时间：
2009-01-15
期刊：
影响因子：
--
通讯作者：
Payne CK
中科院分区：
文献类型：
--
作者：
Jablonski AE;Humphries WH;Payne CK
Quantum dots have been delivered directly across the plasma membrane to the cytosol of living cells using a combination of a cationic peptide, polyarginine, and a hydrophobic counterion, pyrenebutyrate. Quantum dot delivery did not disrupt the plasma membrane and bypassed the barrier of endocytic vesicles. Cellular uptake was independent of temperature, but highly dependent on the surface charge of the quantum dot and the membrane potential of the cell, suggesting a direct translocation across the membrane. This method of delivery can find immediate application for quantum dots and may be broadly applicable to other nanoparticles.
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