Biomolecular analysis with microring resonators: applications in multiplexed diagnostics and interaction screening.

Biomolecular analysis with microring resonators: applications in multiplexed diagnostics and interaction screening.
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DOI:
10.1016/j.cbpa.2013.06.014
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发表时间:
2013-10
影响因子:
7.8
通讯作者:
Bailey, Ryan C.
Bailey, Ryan C.
中科院分区:
生物学2区
文献类型:
--
作者:
Kindt, Jared T.;Bailey, Ryan C.

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硅光子微环谐振器是一类很有前途的传感器,其在生物分析应用中的价值才刚刚开始被探索。微环谐振器在电信行业中用于信号处理应用,由于其可扩展性、灵敏度和多功能性,最近已被重新分配给生物传感任务。它们的传感模式来自光/物质的相互作用--光通过微环传播,所产生的逝去场延伸到结构之外,对局部环境的折射率敏感,局部环境的折射率调制了腔所支持的光的共振波长。这种传感能力最近已被用于检测许多生物目标,包括蛋白质、核酸、病毒和小分子。在这里,我们重点介绍了这项技术在生物传感应用中的一些最令人兴奋的最新用途,并着眼于该领域的未来发展。
Silicon photonic microring resonators are a promising class of sensor whose value in bioanalytical applications has only begun to be explored. Utilized in the telecommunication industry for signal processing applications, microring resonators have more recently been re-tasked for biosensing due to their scalability, sensitivity, and versatility. Their sensing modality arises from light/matter interactions—light propagating through the microring and the resultant evanescent field extending beyond the structure is sensitive to the refractive index of the local environment, which modulates resonant wavelength of light supported by the cavity. This sensing capability has recently been utilized for the detection of numerous biological targets including proteins, nucleic acids, viruses, and small molecules. Herein we highlight some of the most exciting recent uses of this technology for biosensing applications, with an eye towards future developments in the field.
用于定量细胞因子检测和 T 细胞分泌分析的硅光子微环谐振器。
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