Pathophysiology and treatment of septic shock.
Pathophysiology and treatment of septic shock.
复制标题
感染性休克的病理生理学和治疗。
DOI：
10.1001/jama.1991.03470040112032
复制
发表时间：
1991
期刊：
影响因子：
--
通讯作者：
M. Astiz
中科院分区：
文献类型：
--
作者：
E. Rackow;M. Astiz
The mortality from septic shock continues to range between 40% to 60% despite advances in cardiovascular support and antibiotic therapy. Impairment of host defenses predisposes to the development of both severe infection and septic shock. The activation of a myriad of cellular and plasma mediators by microbial toxins produces the systemic and metabolic manifestations of sepsis. The clinical presentation includes characteristic clinical, hemodynamic, and laboratory abnormalities. Multiple organ systems are involved during septic shock, with outcome dependent on the circulatory response and the development of sequential organ failures. Initial resuscitation is directed at restoring tissue perfusion with fluids and vasoactive drugs, guided by assessment of the patient's hemodynamic status. Identification of the site of infection and choice of appropriate antibiotics are critical to the success of therapy. Newer therapeutic modalities include immunologic interventions that attenuate mediator activity and modulate the immune response. Pharmacologic therapies are also being developed that are aimed at blocking the actions of specific mediators.
影响因子：
56.9
作者：
BEUTLER, B;MILSARK, IW;CERAMI, AC
通讯作者：
CERAMI, AC