Insight into the molecular genetics of myopia
Insight into the molecular genetics of myopia
复制标题
深入了解近视的分子遗传学
作者：
Jiali Li;Qingjiong Zhang
近视是全世界最常见的视力损害原因。遗传和环境因素会导致近视的发生。近视的分子遗传学研究已经建立，并暗示了遗传因素的重要作用。通过连锁分析、关联研究、测序分析和实验性近视研究，已经确定了许多与近视相关的位点和基因。迄今为止，还没有基于不同的方法对非综合征性和综合征性近视相关的位点和基因进行系统的综述。这种对近视分子遗传学的系统回顾将为识别其他可能的近视基因提供线索，并帮助我们了解近视的分子机制。本文综述了近年来近视的遗传学研究，总结了所有可能报道的与近视相关的基因和位点，并对未来近视分子遗传学的研究提出了建议。
Myopia is the most common cause of visual impairment worldwide. Genetic and environmental factors contribute to the development of myopia. Studies on the molecular genetics of myopia are well established and have implicated the important role of genetic factors. With linkage analysis, association studies, sequencing analysis, and experimental myopia studies, many of the loci and genes associated with myopia have been identified. Thus far, there has been no systemic review of the loci and genes related to non-syndromic and syndromic myopia based on the different approaches. Such a systemic review of the molecular genetics of myopia will provide clues to identify additional plausible genes for myopia and help us to understand the molecular mechanisms underlying myopia. This paper reviews recent genetic studies on myopia, summarizes all possible reported genes and loci related to myopia, and suggests implications for future studies on the molecular genetics of myopia.
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影响因子：
3.6
作者：
Hsieh YW;Yang XJ
通讯作者：
Yang XJ
影响因子：
1.4
作者：
Ian G. Morgan;R. Kucharski;N. Krongkaew;S. I. Firth;P. Megaw;R. Maleszka
通讯作者：
Ian G. Morgan;R. Kucharski;N. Krongkaew;S. I. Firth;P. Megaw;R. Maleszka
影响因子：
2.2
作者：
Qingjiong Zhang;Xiangming Guo;Xueshan Xiao;Junhui Yi;Xiao-yun Jia;J. Hejtmancik
通讯作者：
Qingjiong Zhang;Xiangming Guo;Xueshan Xiao;Junhui Yi;Xiao-yun Jia;J. Hejtmancik
影响因子：
5.3
作者：
Verhoeven VJ;Hysi PG;Saw SM;Vitart V;Mirshahi A;Guggenheim JA;Cotch MF;Yamashiro K;Baird PN;Mackey DA;Wojciechowski R;Ikram MK;Hewitt AW;Duggal P;Janmahasatian S;Khor CC;Fan Q;Zhou X;Young TL;Tai ES;Goh LK;Li YJ;Aung T;Vithana E;Teo YY;Tay W;Sim X;Rudan I;Hayward C;Wright AF;Polasek O;Campbell H;Wilson JF;Fleck BW;Nakata I;Yoshimura N;Yamada R;Matsuda F;Ohno-Matsui K;Nag A;McMahon G;St Pourcain B;Lu Y;Rahi JS;Cumberland PM;Bhattacharya S;Simpson CL;Atwood LD;Li X;Raffel LJ;Murgia F;Portas L;Despriet DD;van Koolwijk LM;Wolfram C;Lackner KJ;Tönjes A;Mägi R;Lehtimäki T;Kähönen M;Esko T;Metspalu A;Rantanen T;Pärssinen O;Klein BE;Meitinger T;Spector TD;Oostra BA;Smith AV;de Jong PT;Hofman A;Amin N;Karssen LC;Rivadeneira F;Vingerling JR;Eiríksdóttir G;Gudnason V;Döring A;Bettecken T;Uitterlinden AG;Williams C;Zeller T;Castagné R;Oexle K;van Duijn CM;Iyengar SK;Mitchell P;Wang JJ;Höhn R;Pfeiffer N;Bailey-Wilson JE;Stambolian D;Wong TY;Hammond CJ;Klaver CC
通讯作者：
Klaver CC
BMP-2参与近视开发中的硬化重塑。
影响因子：
3.7
作者：
Li H;Cui D;Zhao F;Huo L;Hu J;Zeng J
通讯作者：
Zeng J