Natural History of NAFLD.
Natural History of NAFLD.
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NAFLD的自然历史。
DOI：
10.3390/jcm10061161
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发表时间：
2021-03-10
影响因子：
3.9
通讯作者：
Maurel T
中科院分区：
文献类型：
--
作者：
Pais R;Maurel T
慢性肝病的流行病学和目前的负担正在全球范围内发生变化，非酒精性脂肪性肝病(NAFLD)成为最常见的肝病原因，与肥胖、2型糖尿病和代谢综合征的全球流行密切相关。NAFLD的临床表型非常不同，与疾病进展的多个途径有关。在非酒精性脂肪性肝炎(NASH)缺乏特效治疗的情况下，了解疾病的自然病史、识别和优化控制疾病进展的因素是很重要的。本文对非酒精性脂肪肝患者的肝损害进展和肝外并发症(心血管疾病、肝外肿瘤)的发生进行了关键性的分析。我们还简要讨论了NAFLD临床表型的异质性对全球和个体水平的临床实践的影响。
The epidemiology and the current burden of chronic liver disease are changing globally, with non-alcoholic fatty liver disease (NAFLD) becoming the most frequent cause of liver disease in close relationship with the global epidemics of obesity, type 2 diabetes and metabolic syndrome. The clinical phenotypes of NAFLD are very heterogeneous in relationship with multiple pathways involved in the disease progression. In the absence of a specific treatment for non-alcoholic steatohepatitis (NASH), it is important to understand the natural history of the disease, to identify and to optimize the control of factors that are involved in disease progression. In this paper we propose a critical analysis of factors that are involved in the progression of the liver damage and the occurrence of extra-hepatic complications (cardiovascular diseases, extra hepatic cancer) in patients with NAFLD. We also briefly discuss the impact of the heterogeneity of the clinical phenotype of NAFLD on the clinical practice globally and at the individual level.
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影响因子：
9.8
作者：
Adams, Leon A.;Harmsen, Scott;St Sauver, Jennifer L.;Charatcharoenwitthaya, Phunchai;Enders, Felicity B.;Therneau, Terry;Angulo, Paul
通讯作者：
Angulo, Paul
影响因子：
6.9
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通讯作者：
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影响因子：
25.7
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通讯作者：
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29.4
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通讯作者：
Bendtsen F
影响因子：
15.9
作者：
Caussy, Cyrielle;Soni, Meera;Loomba, Rohit
通讯作者：
Loomba, Rohit