SARS-CoV-2 Variant Exposures Elicit Antibody Responses With Differential Cross-Neutralization of Established and Emerging Strains Including Delta and Omicron.
SARS-CoV-2 Variant Exposures Elicit Antibody Responses With Differential Cross-Neutralization of Established and Emerging Strains Including Delta and Omicron.
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DOI：
10.1093/infdis/jiab635
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发表时间：
2022-06-01
期刊：
影响因子：
--
通讯作者：
DeRisi J
中科院分区：
文献类型：
--
作者：
Laurie MT;Liu J;Sunshine S;Peng J;Black D;Mitchell AM;Mann SA;Pilarowski G;Zorn KC;Rubio L;Bravo S;Marquez C;Sabatino JJ;Mittl K;Petersen M;Havlir D;DeRisi J
The wide spectrum of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with phenotypes impacting transmission and antibody sensitivity necessitates investigation of immune responses to different spike protein versions. Here, we compare neutralization of variants of concern, including B.1.617.2 (delta) and B.1.1.529 (omicron), in sera from individuals exposed to variant infection, vaccination, or both. We demonstrate that neutralizing antibody responses are strongest against variants sharing certain spike mutations with the immunizing exposure, and exposure to multiple spike variants increases breadth of variant cross-neutralization. These findings contribute to understanding relationships between exposures and antibody responses and may inform booster vaccination strategies. This study characterizes neutralization of 8 different SARS-CoV-2 variants, including delta and omicron, with respect to 9 different prior exposures, including vaccination, booster, and infections with delta, epsilon, and others. Different exposures were found to confer substantially differing neutralization specificity.
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影响因子：
64.5
作者：
Liu C;Ginn HM;Dejnirattisai W;Supasa P;Wang B;Tuekprakhon A;Nutalai R;Zhou D;Mentzer AJ;Zhao Y;Duyvesteyn HME;López-Camacho C;Slon-Campos J;Walter TS;Skelly D;Johnson SA;Ritter TG;Mason C;Costa Clemens SA;Gomes Naveca F;Nascimento V;Nascimento F;Fernandes da Costa C;Resende PC;Pauvolid-Correa A;Siqueira MM;Dold C;Temperton N;Dong T;Pollard AJ;Knight JC;Crook D;Lambe T;Clutterbuck E;Bibi S;Flaxman A;Bittaye M;Belij-Rammerstorfer S;Gilbert SC;Malik T;Carroll MW;Klenerman P;Barnes E;Dunachie SJ;Baillie V;Serafin N;Ditse Z;Da Silva K;Paterson NG;Williams MA;Hall DR;Madhi S;Nunes MC;Goulder P;Fry EE;Mongkolsapaya J;Ren J;Stuart DI;Screaton GR
通讯作者：
Screaton GR
影响因子：
5.5
作者：
Wu K;Choi A;Koch M;Elbashir S;Ma L;Lee D;Woods A;Henry C;Palandjian C;Hill A;Jani H;Quinones J;Nunna N;O'Connell S;McDermott AB;Falcone S;Narayanan E;Colpitts T;Bennett H;Corbett KS;Seder R;Graham BS;Stewart-Jones GBE;Carfi A;Edwards DK
通讯作者：
Edwards DK
影响因子：
9.2
作者：
Kalantar KL;Carvalho T;de Bourcy CFA;Dimitrov B;Dingle G;Egger R;Han J;Holmes OB;Juan YF;King R;Kislyuk A;Lin MF;Mariano M;Morse T;Reynoso LV;Cruz DR;Sheu J;Tang J;Wang J;Zhang MA;Zhong E;Ahyong V;Lay S;Chea S;Bohl JA;Manning JE;Tato CM;DeRisi JL
通讯作者：
DeRisi JL
DOI：
10.1126/science.abj0299
发表时间：
2021-09-17
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Corbett KS;Nason MC;Flach B;Gagne M;O'Connell S;Johnston TS;Shah SN;Edara VV;Floyd K;Lai L;McDanal C;Francica JR;Flynn B;Wu K;Choi A;Koch M;Abiona OM;Werner AP;Moliva JI;Andrew SF;Donaldson MM;Fintzi J;Flebbe DR;Lamb E;Noe AT;Nurmukhambetova ST;Provost SJ;Cook A;Dodson A;Faudree A;Greenhouse J;Kar S;Pessaint L;Porto M;Steingrebe K;Valentin D;Zouantcha S;Bock KW;Minai M;Nagata BM;van de Wetering R;Boyoglu-Barnum S;Leung K;Shi W;Yang ES;Zhang Y;Todd JM;Wang L;Alvarado GS;Andersen H;Foulds KE;Edwards DK;Mascola JR;Moore IN;Lewis MG;Carfi A;Montefiori D;Suthar MS;McDermott A;Roederer M;Sullivan NJ;Douek DC;Graham BS;Seder RA
通讯作者：
Seder RA
影响因子：
46.9
作者：
Elledge SK;Zhou XX;Byrnes JR;Martinko AJ;Lui I;Pance K;Lim SA;Glasgow JE;Glasgow AA;Turcios K;Iyer NS;Torres L;Peluso MJ;Henrich TJ;Wang TT;Tato CM;Leung KK;Greenhouse B;Wells JA
通讯作者：
Wells JA