Photonic crystal enhanced fluorescence for early breast cancer biomarker detection.
Photonic crystal enhanced fluorescence for early breast cancer biomarker detection.
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DOI：
10.1002/jbio.201200037
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发表时间：
2012-08
影响因子：
2.8
通讯作者：
Zangar, Richard C.
中科院分区：
文献类型：
--
作者：
Cunningham, Brian T.;Zangar, Richard C.
光子晶体表面为提高疾病诊断中使用的基于表面的荧光测定的灵敏度提供了一个引人注目的平台。通过光子晶体增强激发和增强萃取的互补过程，周期性介电基纳米结构表面可以同时增加表面结合荧光团所经历的电场强度，提高发射荧光光子的收集效率。通过在大量表面区域上廉价制造光子晶体表面的能力，它们适用于生物传感中的一次性应用，例如血清中的疾病生物标志物检测。在这篇综述中，我们将描述在乳腺癌诊断中实施高灵敏度、多路生物标志物检测的动机。我们将总结最近通过使用光子晶体表面来提高检测限的努力。检测限的降低是由光子晶体制造的低自荧光衬底和利用其独特功能的检测仪器驱动的。
Photonic crystal surfaces offer a compelling platform for improving the sensitivity of surface-based fluorescent assays used in disease diagnostics. Through the complementary processes of photonic crystal enhanced excitation and enhanced extraction, a periodic dielectric-based nanostructured surface can simultaneously increase the electric field intensity experienced by surface-bound fluorophores and increase the collection efficiency of emitted fluorescent photons. Through the ability to inexpensively fabricate photonic crystal surfaces over substantial surface areas, they are amenable to single-use applications in biological sensing, such as disease biomarker detection in serum. In this review, we will describe the motivation for implementing high-sensitivity, multiplexed biomarker detection in the context of breast cancer diagnosis. We will summarize recent efforts to improve the detection limits of such assays though the use of photonic crystal surfaces. Reduction of detection limits is driven by low autofluorescent substrates for photonic crystal fabrication, and detection instruments that take advantage of their unique features.
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