Association between statin use and uveitis: results from the Pacific Ocular Inflammation study.
Association between statin use and uveitis: results from the Pacific Ocular Inflammation study.
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DOI：
10.1016/j.ajo.2015.01.009
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发表时间：
2015-04
影响因子：
4.2
通讯作者：
Acharya, Nisha R.
中科院分区：
文献类型：
--
作者：
Borkar, Durga S.;Tham, Vivien M.;Shen, Elizabeth;Parker, John V.;Uchida, Aileen;Vinoya, Aleli C.;Acharya, Nisha R.
为了评估他汀类药物使用与葡萄膜炎诊断之间是否存在保护性关联，回顾性、基于人群的病例对照研究，对2006年1月1日至2007年12月31日期间Kaiser Permanente夏威夷健康计划中所有患者（N= 217，061）的病历进行电子检索，以获得国际疾病分类第9版，与葡萄膜炎相关的诊断代码。进行病历审查，以确认研究期间发生的葡萄膜炎诊断。以5：1的比例随机选择两个对照组，对照组被分配一个索引日期，以匹配各自的病例诊断日期。一个对照组选自在研究期间至少有一次医疗保健访视的一般Kaiser Permanente夏威夷人群。另一个对照组选自Kaiser Permanente夏威夷成员，他们在研究期间至少有一次到眼科诊所就诊。他汀类药物使用定义为基于电子检索Kaiser Permanente夏威夷药房数据库中的通用产品识别代码，在诊断或索引日期前一年内填写他汀类药物处方。以葡萄膜炎临床诊断为结局的条件Logistic回归模型用于评估他汀类药物使用与葡萄膜炎之间的关系。确定了108例葡萄膜炎事件病例。19%的葡萄膜炎患者在诊断前一年内使用过他汀类药物，而一般Kaiser人群对照组患者为30%（p=0.03），眼科诊所对照组患者为38%（p<0.001）。使用一般Kaiser人群对照并调整年龄，性别，种族和自身免疫性疾病，他汀类药物使用者发生葡萄膜炎的几率比非他汀类药物使用者发生葡萄膜炎的几率低48%（OR：0.52，95%CI：0.29至0.94，p=0.03）。同样，当调整这些因素并使用眼科诊所对照组时，他汀类药物使用者发生葡萄膜炎的几率比非他汀类药物使用者低33%（OR：0.67，95%CI：0.38至1.19，p=0.17）。他汀类药物的使用可能对葡萄膜炎的发展有保护作用。几种抗炎和免疫调节机制可以解释这种关联。
To assess whether there is a protective association between statin use and uveitis diagnosis Retrospective, population-based case-control study Medical records of all patients in the Kaiser Permanente Hawaii health plan between January 1, 2006 and December 31, 2007 (N=217,061) were searched electronically for International Classification of Diseases, 9th Revision, diagnosis codes related to uveitis. Chart review was done to confirm incident uveitis diagnosis during the study period. Two control groups were each randomly selected at a 5:1 ratio to cases, and controls were assigned an index date to match their respective case diagnosis date. One control group was selected from the general Kaiser Permanente Hawaii population that had at least one healthcare visit during the study period. Another control group was selected from the population of Kaiser Permanente Hawaii members who had at least one visit to the ophthalmology clinic during the study period. Statin use was defined as filling a prescription for statin medication in the year prior to the diagnosis or index date based on an electronic search of the Kaiser Permanente Hawaii pharmacy database for Generic Product Identification codes. A conditional logistic regression model with clinical diagnosis of uveitis as the outcome was used to assess the relationship between statin use and uveitis. One hundred eight incident cases of uveitis were identified. Nineteen percent of uveitis patients had used statin medication in the year prior to diagnosis compared to 30% of patients in the general Kaiser population control (p=0.03) and 38% of patients in the ophthalmology clinic control (p<0.001). Using the general Kaiser population control and adjusting for age, gender, race, and autoimmune diseases, the odds of a statin user developing uveitis were 48% less than the odds of a non-statin user developing uveitis (OR: 0.52, 95% CI: 0.29 to 0.94, p=0.03). Similarly, the odds of developing uveitis were 33% less for statin users compared to non-statin users (OR: 0.67, 95% CI: 0.38 to 1.19, p=0.17) when adjusting for these factors and using the ophthalmology clinic control group. Statin use may be protective against the development of uveitis. Several anti-inflammatory and immunomodulatory mechanisms may explain this association.
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影响因子：
3.1
作者：
Carey, F. J.;Little, M. W.;Hart, A. R.
通讯作者：
Hart, A. R.
影响因子：
3.4
作者：
Kohno, Hideo;Sakai, Tsutomu;Kitahara, Kenji
通讯作者：
Kitahara, Kenji
影响因子：
13.7
作者：
Leung, Dexter Y. L.;Li, Felix C. H.;Lam, Dennis S. C.
通讯作者：
Lam, Dennis S. C.
影响因子：
8.1
作者：
Leuschen, Jessica;Mortensen, Eric M.;Mansi, Ishak
通讯作者：
Mansi, Ishak
影响因子：
8.8
作者：
Gaist, D.;Andersen, L.;Friis, S.
通讯作者：
Friis, S.