Quantitative assessment of conjunctival microvascular circulation of the human eye.
Quantitative assessment of conjunctival microvascular circulation of the human eye.
复制标题
人眼的结膜微血管循环的定量评估。
DOI：
10.1016/j.mvr.2009.12.003
复制
发表时间：
2010-03
影响因子：
3.1
通讯作者：
Wu T
中科院分区：
文献类型：
--
作者：
Shahidi M;Wanek J;Gaynes B;Wu T
球结膜微血管的可获得性为评估大脑皮质的血液供应提供了一种手段，从而优化了旨在预防或降低脑血管疾病和中风风险的治疗干预措施。本文报道了一种定量测量人眼结膜血管直径、血流速度和流量的方法的可行性。该方法基于裂隙灯生物显微镜数字成像和时空图像分析技术。以50赫兹的频率采集一系列的结膜微血管图像。分析图像以确定血管直径、速度和流量。血管直径测量范围为8.7至24.3微米，平均值为15.5微米。血流量在27.3~296.9 pl/S之间，平均值为111.8 pl/S，血流量与血管内径呈幂函数关系(R=0.87)。这项技术在体内血流动力学定量评估中的应用对各种心血管和血液疾病的诊断和监测具有潜在的影响。
Accessibility to the bulbar conjunctival microvasculature provides a means to assess blood supply to the cerebral cortex and thus optimize therapeutic interventions designed to prevent or reduce the risk of cerebral vascular disease and stroke. The feasibility of a method for quantitative measurements of conjunctiva blood vessel diameter, blood velocity, and flow in the human eye is reported. The method is based on slit lamp biomicroscope digital imaging coupled with a space time image analysis technique. A sequence of conjunctiva microvasculature images were captured at a rate of 50 Hz. The images were analyzed to determine blood vessel diameter, velocity and flow. Blood vessel diameter measurements ranged between 8.7 and 24.3 microns, with a mean value of 15.5 microns. Blood flow rate ranged between 27.3 and 296.9 pl/s, with a mean value of 111.8 pl/s. The relationship between blood flow and vessel diameter was fit with a power law curve (R = 0.87). The application of this technique for in vivo quantitative assessment of blood flow dynamics has potential to impact diagnosis and monitoring of various cardiovascular and blood disorders.
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影响因子：
15.9
作者：
Embury, SH;Mohandas, N;Cheung, ATW
通讯作者：
Cheung, ATW
影响因子：
2.4
作者：
Japee, SA;Pittman, RN;Ellis, CG
通讯作者：
Ellis, CG
影响因子：
20.3
作者：
Cheung, ATW;Harmatz, P;Vichinsky, EP
通讯作者：
Vichinsky, EP
影响因子：
4.3
作者：
Schaser, KD;Settmacher, U;Haas, NP
通讯作者：
Haas, NP
影响因子：
2.4
作者：
Japee, SA;Pittman, RN;Ellis, CG
通讯作者：
Ellis, CG