Polygenic Risk for Depression is Associated with the Severity and Rate of Change in Depressive Symptoms Across Adolescence
Polygenic Risk for Depression is Associated with the Severity and Rate of Change in Depressive Symptoms Across Adolescence
复制标题
抑郁症的多基因风险与青春期抑郁症状的严重程度和变化率有关
DOI：
10.1101/2019.12.31.19016212
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Kwong A
中科院分区：
文献类型：
--
作者：
Kwong A
背景青春期是抑郁症通常发作的时期，以前使用双胞胎研究的研究表明，遗传影响在抑郁症如何在青春期发展和变化中发挥作用。最近的全基因组关联研究也表明，常见的遗传变异-可以作为多基因风险评分（PRS）-也与抑郁症有关。然而，PRS在青少年抑郁症中的作用以及青少年抑郁症的变化尚不清楚。本研究的目的是检查青少年和青年期抑郁症状的PRS和抑郁症状之间的关联，以及多基因风险如何与抑郁症状的变化相关，使用两种方法：横截面分析和多层次增长曲线模型，以检查随着时间的推移变化率。方法使用数据从超过6000名参与者的雅芳纵向研究的父母和孩子（ALSPAC），我们研究了抑郁症状的遗传易感性（抑郁症状的多基因风险评分（PRS））和自我报告的抑郁症状（10-24岁的9次简短情绪和感觉问卷）之间的关联。我们研究了横截面协会在每个年龄和轨迹的抑郁症状在一个重复的措施框架，使用增长曲线analysis.ResultsThe PRS与抑郁症状在整个青春期和青年期的横截面和增长曲线分析，虽然协会更强，在后者的分析。生长曲线分析还提供了额外的见解，表明个人具有较高的PRS有陡峭的轨迹，整个青春期的抑郁症状，更大的增长率的changes.ConclusionsIn一项纵向研究跨越青春期到成年早期的生活，这些结果表明，共同的遗传变异索引的PRS抑郁症状的影响都在青少年抑郁症状的变化率的严重程度。纵向数据，利用重复测量设计有可能提供洞察的因素，影响青少年抑郁症的发病和持续性。
BackgroundAdolescence marks a period where depression will commonly onset and previous research using twin studies has suggested that genetic influences play a role in how depression develops and changes across adolescence. Recent genome-wide association studies have also shown that common genetic variants – which can be brought together as polygenic risk scores (PRS) – are also implicated in depression. However, the role of PRS in adolescent depression and changes in adolescent depression is not yet understood. The aim of this study was to examine the association between a PRS for depressive symptoms and depressive symptoms across adolescence and young adulthood, and how polygenic risk is associated with changes in depressive symptoms using two methods: cross-sectional analysis and multilevel growth curve modelling to examine the rate of change over time.MethodsUsing data from over 6000 participants of the Avon Longitudinal Study of Parents and Children (ALSPAC) we examined associations between genetic liability to depressive symptoms (polygenic risk score (PRS) for depressive symptoms) and self-reported depressive symptoms (short mood and feelings questionnaire over 9 occasions from 10-24 years). We examined cross-sectional associations at each age and trajectories of depressive symptoms in a repeated measures framework using growth curve analysis.ResultsThe PRS was associated with depressive symptoms throughout adolescence and young adulthood in both cross-sectional and growth curve analyses, though associations were stronger in the latter analyses. Growth curve analyses also provided additional insights, demonstrating that individuals with a higher PRS had steeper trajectories of depressive symptoms across adolescence with a greater increasing rate of change.ConclusionsIn a longitudinal study spanning adolescence to early adult life, these results show that common genetics variants as indexed by a PRS for depressive symptoms influence both the severity of rate of change in adolescent depressive symptoms. Longitudinal data that make use of repeated measures designs have the potential to provide insights into the factors that influence the onset and persistence of adolescent depression.
登录
查看更多内容
从青春期到青年期的抑郁症状轨迹：自尊和身体相关预测因素的作用
影响因子：
4.9
作者：
J. Rawana;A. Morgan
通讯作者：
A. Morgan
影响因子：
6.6
作者：
Hill, Ryan M.;Pettit, Jeremy W.;Lewinsohn, Peter M.;Seeley, John R.;Klein, Daniel N.
通讯作者：
Klein, Daniel N.
影响因子：
--
作者：
Kessler, RC;Berglund, P;Walters, EE
通讯作者：
Walters, EE
影响因子：
17.7
作者：
Weissman, Myrna M.;Wickramaratne, Priya;Talati, Ardesheer
通讯作者：
Talati, Ardesheer
影响因子：
3.5
作者：
Paternoster L;Howe LD;Tilling K;Weedon MN;Freathy RM;Frayling TM;Kemp JP;Smith GD;Timpson NJ;Ring SM;Evans DM;Lawlor DA
通讯作者：
Lawlor DA