Distinct clinicopathologic characteristics of diffuse- and intestinal-type gastric cancer in Taiwan.
Distinct clinicopathologic characteristics of diffuse- and intestinal-type gastric cancer in Taiwan.
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台湾弥漫型和肠型胃癌的独特临床病理特征。
DOI：
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发表时间：
1997
影响因子：
2.9
通讯作者：
J. T. Lin
中科院分区：
文献类型：
--
作者：
M. S. Wu;K. C. Yang;C. Shun;T. Hsiao;C. C. Lin;H. ;S. Chuang;W. J. Lee;J. T. Lin
对221例肠型（IT）胃癌与290例弥漫型（DT）胃癌的临床病理特征进行回顾性比较。肠道类型的特点是平均年龄较大（65.0 +/- 10.8岁vs. 56.2 +/- 13岁），男女比例较高（2.56 vs. 1.06），以O型血为主（46.2% vs. 31.1%），经常吸烟（50.7% vs. 31.4%）和饮酒（28.5% vs. 17.6%）。相比之下，DT组的父母或兄弟姐妹胃癌阳性病史（9.3%比4.1%）和a血型（40.3%比27.6%）的频率高于IT组。DT的显著组织学特征包括Borrmann IV型较多（13.1%比1.3%），Borrmann I型较少（1%比7.2%），更常见的累及中三分之一（26.9%比15.9%）和整个胃（4.1%比0%），更多的腹膜播散（15.5%比9%）、淋巴结转移（67.2%比51%）和神经渗透（34.1%比24.4%），但与IT相比幽门螺杆菌感染较少（55.9%比69.2%）。在肿瘤浸润深度、静脉渗透、十二指肠受累和术后生存方面，IT和DT没有差异。台湾的IT和DT的这些不同的临床病理特征提示这两种组织学亚型的胃癌存在不同的致病过程。
The clinicopathologic features of 221 patients with intestinal-type (IT) gastric cancer were compared retrospectively with those of 290 diffuse type (DT). Intestinal type was characterized by an older mean age (65.0 +/- 10.8 years vs. 56.2 +/- 13 years), a higher male-female ratio (2.56 vs. 1.06), predominance of blood group O (46.2% vs. 31.1%), and frequent habitual smoking (50.7% vs. 31.4%) and drinking (28.5% vs. 17.6%) than did DT. In contrast, DT had a higher frequency of positive history of parent or sibling with gastric cancer (9.3% vs. 4.1%) and blood group A (40.3% vs. 27.6%) than did IT. The distinguishing histologic features of DT included more Borrmann type IV (13.1% vs. 1.3%) but less Borrmann type I (1% vs. 7.2%), more frequent involvement of middle third (26.9% vs. 15.9%) and whole stomach (4.1% vs. 0%), and more peritoneal seeding (15.5% vs. 9%), lymph node metastasis (67.2% vs. 51%), and nerve permeation (34.1% vs. 24.4%), but less Helicobacter pylori infection (55.9% vs. 69.2%) when compared with those of IT. There was no difference in depth of tumor invasion, venous permeation, duodenal involvement, and postoperative survival between IT and DT. These distinct clinicopathologic features between IT and DT in Taiwan suggest the presence of a different pathogenic process for these two histologic subtypes of gastric cancer.
影响因子：
29.4
作者：
LOCKE, GR;TALLEY, NJ;MELTON, J
通讯作者：
MELTON, J
影响因子：
158.5
作者：
NOMURA, A;STEMMERMANN, GN;BLASER, MJ
通讯作者：
BLASER, MJ