Amide Proton Transfer MRI Signal as a Surrogate Biomarker of Ischemic Stroke Recovery in Patients With Supportive Treatment
Amide Proton Transfer MRI Signal as a Surrogate Biomarker of Ischemic Stroke Recovery in Patients With Supportive Treatment
复制标题
酰胺质子转移 MRI 信号作为支持治疗患者缺血性中风恢复的替代生物标志物
DOI：
10.3389/fneur.2019.00104
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发表时间：
2019-02
影响因子：
3.4
通讯作者：
Li Chunmei
中科院分区：
文献类型：
--
作者：
Yu Lu;Chen Yuhui;Chen Min;Luo Xiaojie;Jiang Shanshan;Zhang Yi;Chen Haibo;Gong Tao;Zhou Jinyuan;Li Chunmei
背景：酰胺质子转移(APT)磁共振成像因其对酸性环境的敏感性而在评估中风严重程度方面显示出巨大的潜力。然而，这项前景看好的MRI技术还没有被用于评估中风康复方面的治疗效果。目的：应用pH敏感型APT磁共振成像技术评价缺血性卒中患者支持治疗的疗效。材料和方法：选择43例早期缺血性卒中患者，在治疗前3T行常规和APT序列扫描。治疗结束后，26例患者进行了随诊MRI扫描(不同天次扫描1~3次)。测量了3.5ppm的磁化传递比不对称性，通常称为APTW信号。分析治疗前后APTW信号的变化。结果：梗死灶APTW基线信号强度与基线卒中严重程度呈负相关。24例(92.3%)患者随时间延长，病灶APTW值逐渐升高，临床症状明显改善。2例(7.7%)随诊时APTW信号进一步降低，并伴有临床症状加重。与基线相比，所有治疗后患者的APTW信号都显著增加(有效)，无论是基于治疗后还是中风发作时间。缺血性卒中患者治疗后APTW信号增强与临床症状改善有关。结论：APTW信号可作为评价缺血性卒中治疗效果的一种有用的影像生物标志物。
Background: Amide proton transfer (APT) MR imaging has shown great potential in the evaluation of stroke severity because of its sensitivity to acid environments. However, this promising MRI technique has not been used to assess treatment efficacy with regard to stroke recovery. Purpose: To assess the therapeutic effect of supportive treatment in ischemic stroke patients using the pH-sensitive APT MRI technique. Material and Methods: Forty-three ischemic stroke patients at an early stage were recruited and scanned with conventional and APT MRI sequences at 3T before treatment. After treatment, 26 patients underwent a follow-up MRI scan (one to three times on different days). The magnetization-transfer-ratio asymmetry at 3.5 ppm, usually called the APT-weighted (APTW) signal, was measured. The APTW signal changes following treatment were analyzed. Results: Baseline APTW signal intensities in the infarcted lesions inversely correlated with baseline stroke severity. Lesion APTW values gradually increased with time in 24 cases (92.3%) with a follow-up MRI scan, showing clinical symptom improvements. Two cases (7.7%) showed further decreased APTW signal in the follow-up scan, accompanied by clinical symptom aggravation. Compared to the baseline, significant APTW signal increases were found for all post-treatment patients (efficacious), whether based on post-treatment or on stroke onset times. The increase in APTW signal in the ischemic stroke lesion after treatment was associated with an improvement in clinical symptoms. Conclusion: The APTW signal would be a useful imaging biomarker by which to assess the therapeutic efficacy of ischemic stroke treatment.
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DOI：
10.1385/1-59259-933-8:111
发表时间：
2005
期刊：
--
影响因子：
--
作者：
M. Flaherty;E. Jauch;R. Kothari;J. Broderick
通讯作者：
M. Flaherty;E. Jauch;R. Kothari;J. Broderick
影响因子：
8.3
作者：
Soize, Sebastien;Tisserand, Marie;Oppenheim, Catherine
通讯作者：
Oppenheim, Catherine
影响因子：
3.3
作者：
Zong, Xiaopeng;Wang, Ping;Kim, Seong-Gi;Jin, Tao
通讯作者：
Jin, Tao
影响因子：
3.3
作者：
Heo HY;Zhang Y;Jiang S;Lee DH;Zhou J
通讯作者：
Zhou J
影响因子：
8.3
作者：
Jiang Q;Zhang ZG;Chopp M
通讯作者：
Chopp M