Delayed sustained drug release from electrostatic powder coated tablets with ultrafine polymer blends
Delayed sustained drug release from electrostatic powder coated tablets with ultrafine polymer blends
复制标题
超细聚合物共混物静电粉末包衣片剂的延迟持续药物释放
DOI：
10.1016/j.powtec.2021.08.088
复制
发表时间：
2021-08
影响因子：
5.2
通讯作者：
Jesse Zhu
中科院分区：
文献类型：
--
作者：
Qingliang Yang;Feng Yuan;Jiale Chen;Hang Zhou;Gensheng Yang;Jesse Zhu
本研究的目的是应用静电干粉包衣工艺将阿司匹林片剂与聚合物共混物包衣，以产生单层包衣膜，这可能允许有利的延迟持续药物释放曲线。成功开发并优化了含有肠溶聚合物（羟丙基甲基纤维素邻苯二甲酸酯或羟丙基甲基纤维素乙酸-琥珀酸酯）和不溶性聚合物（Eudragit® RL）的聚合物共混物的包衣制剂。扫描电子显微镜和耐酸性测试结果表明，固化条件对所制得的涂膜质量有显著影响。药物溶出实验表明，改变包衣水平和包衣制剂与肠溶聚合物的不溶性聚合物的不同比例实现了改变和可调节的药物释放曲线。所有的结果表明，静电粉末包衣技术是能够产生一个令人满意的包衣膜与聚合物共混物，允许一个有利的功能，延迟持续药物释放。
The present study aims to apply an electrostatic dry powder coating process to coat aspirin tablets with polymer blends to produce a single-layer coating film, which potentially allows an advantageous delayed sustained drug release profile. The coating formulations containing polymer blends of enteric polymer (hydroxypropyl methylcellulose phthalate or hydroxypropyl methyl cellulose acetate-succinate) and insoluble polymer (Eudragit® RL) were successfully developed and optimized. Results of scanning electron microscopy and acid resistance test demonstrated that curing conditions had a significant impact on the qualities of the produced film. Drug dissolution experiments revealed that changes in the coating level and the coating formulation with different ratios of the enteric polymer to the insoluble polymer achieved an altered and adjustable drug release profile. All of the results suggested that electrostatic powder coating technology is capable to produce a satisfactory coating film with polymer blends, allowing an advantageous functionality of delayed sustained drug release.
登录
查看更多内容
影响因子：
5.8
作者：
H. Kranz;S. Gutsche
通讯作者：
H. Kranz;S. Gutsche
影响因子：
5.8
作者：
R. Wulff;Claudia S. Leopold
通讯作者：
R. Wulff;Claudia S. Leopold
影响因子：
3.4
作者：
Khan, MZI;Stedul, HP;Kurjakovic, N
通讯作者：
Kurjakovic, N
影响因子：
4.6
作者：
Eckelt, A.;Eckelt, J.;Wolf, B. A.
通讯作者：
Wolf, B. A.
影响因子：
4.6
作者：
Qingliang Yang;Yingliang Ma;Jesse Zhu
通讯作者：
Qingliang Yang;Yingliang Ma;Jesse Zhu