Aromatic amino acid metabolism of neonatal piglets receiving TPN: effect of tyrosine precursors.
Aromatic amino acid metabolism of neonatal piglets receiving TPN: effect of tyrosine precursors.
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接受 TPN 的新生仔猪的芳香氨基酸代谢：酪氨酸前体的影响。
DOI：
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发表时间：
1994
影响因子：
--
通讯作者：
P. Pencharz
中科院分区：
文献类型：
--
作者：
L. Wykes;J. House;R. Ball;P. Pencharz
酪氨酸在总肠外营养（TPN）溶液中的溶解度低，使满足婴儿芳香族氨基酸的需求复杂化。本研究比较了两种酪氨酸前体对tpn喂养新生仔猪芳香族氨基酸需求的影响，并以添加苯丙氨酸（Phe）满足总芳香族氨基酸需求的对照组为对照。18头3日龄公约克郡仔猪（6头/组）经中心静脉注射TPN，连续8 d。溶液中加入苯丙氨酸或以下两种酪氨酸前体之一：n -乙酰基酪氨酸（n - actir）或甘氨酸基酪氨酸（GlyTyr）。测定了芳香族氨基酸代谢、生长和氮利用率。氨基酸和能量的平均摄入量为14.6 g.kg-1。和1,050 kJ.kg-1.day-1。对照组和GlyTyr组仔猪氮平衡和氮利用率显著高于对照组（P < 0.05）。尿中n - actir的高排泄量（65%）证实了其低生物利用度。Phe组的通量和氧化水平显著高于对照组（P < 0.05）。高血浆苯丙氨酸水平和苯丙氨酸分解产物的排泄，以及GlyTyr组的高血浆酪氨酸，表明目前用于满足TPN新生儿芳香族氨基酸需求的策略需要进一步完善。
Low tyrosine solubility in total parenteral nutrition (TPN) solutions complicates meeting the aromatic amino acid needs of infants. This study compared the effectiveness of two tyrosine precursors to supply the aromatic amino acid needs of TPN-fed neonatal piglets with a control group in which total aromatic acid needs were met by the addition of phenylalanine (Phe). Eighteen 3-day-old male Yorkshire piglets (6/group) received TPN for 8 days by central line. The solution was supplemented with Phe or one of the following two tyrosine precursors: N-acetyltyrosine (N-AcTyr) or glycyltyrosine (GlyTyr). Aromatic amino acid metabolism, growth, and nitrogen utilization were measured. Average amino acid and energy intakes were 14.6 g.kg-1.day-1 and 1,050 kJ.kg-1.day-1. Nitrogen balance and utilization were significantly higher (P < 0.05) in piglets in the control Phe group and on the GlyTyr regimen. The high urinary excretion of N-AcTyr (65%) confirms its low bioavailability. Flux and oxidation were significantly higher (P < 0.05) in the Phe group. High plasma Phe levels and excretion of Phe catabolites, as well as the high plasma tyrosine in the GlyTyr group, indicate that current strategies employed to meet the aromatic amino acid needs of neonates on TPN need further refinement.
接受长期肠外营养的儿童的血浆氨基酸浓度。
DOI：
10.1097/00005176-198809000-00021
发表时间：
1988
影响因子：
2.9
作者：
Dahlström,KA;Ament,ME;Laidlaw,SA;Kopple,JD
通讯作者：
Kopple,JD