Investigating sex differences and the effect of drug exposure order in the sensory reward-enhancing effects of nicotine and d-amphetamine alone and in combination.
Investigating sex differences and the effect of drug exposure order in the sensory reward-enhancing effects of nicotine and d-amphetamine alone and in combination.
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DOI：
10.1016/j.neuropharm.2021.108845
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发表时间：
2022-01-01
影响因子：
4.7
通讯作者：
Bevins RA
中科院分区：
文献类型：
--
作者：
McNealy KR;Houser SD;Barrett ST;Bevins RA
尼古丁增强了其他环境刺激的奖励效应；这种奖励增强鼓励并维持尼古丁的消耗。尼古丁的使用先于其他精神兴奋剂的使用，但接受兴奋剂处方也预示着未来会吸烟。在此之前，没有研究调查过药物暴露顺序对奖励增强的影响，尼古丁和d-安非他明也没有。因此，我们的目的是研究药物暴露顺序如何影响尼古丁和d-安非他明单独和联合的奖励增强作用。我们使用了20只雄性和20只雌性Sprague-Dawley大鼠。在实验前注射d-安非他明（Sal, 0.1、0.3或0.6 mg/kg）或尼古丁（Sal, 0.03、0.06、0.1、0.3 mg/kg）后，通过检查视觉刺激强化物维持的反应，在受试者内部研究增强效果。20只大鼠（10 M, 10 F）在d-安非他明前完成尼古丁增强试验。另外20只大鼠（10只M， 10只F）在尼古丁之前完成了d-安非他明的测试。在这些阶段之后，大鼠在会议前注射两次：一种是d-安非他明（Sal, 0.1, 0.3或0.6 mg/kg），另一种是尼古丁（Sal, 0.03, 0.06, 0.1或0.3 mg/kg）。在服用尼古丁之前服用安非他明会增加尼古丁的奖励增强作用。d-安非他明对雌性小鼠的奖励增强作用更大，但对暴露顺序没有影响。在相互作用阶段，雌性在服用安非他明之前服用尼古丁会增强尼古丁和d-安非他明之间的相互作用，而雄性在服用尼古丁之前服用安非他明会增强这种相互作用。由此可见，在治疗尼古丁依赖和检查涉及尼古丁和d-安非他明的多物质使用的驱动因素时，除了性行为外，还应考虑以前和目前使用安非他明的情况。
Nicotine enhances the rewarding effects of other environmental stimuli; this reward-enhancement encourages and maintains nicotine consumption. Nicotine use precedes other psychostimulant use, but receiving a stimulant prescription also predicts future smoking. Previously, no study has investigated effects of drug exposure order in reward-enhancement, nor with nicotine and d-amphetamine. Thus, we aimed to investigate how drug exposure order impacted the reward-enhancing effects of nicotine and d-amphetamine, alone and in combination. We used 20 male and 20 female Sprague-Dawley rats. Enhancement was investigated within-subjects by examining responding maintained by a visual stimulus reinforcer following a pre-session injection of either d-amphetamine (Sal, 0.1, 0.3, or 0.6 mg/kg) or nicotine (Sal, 0.03, 0.06, 0.1, 0.3 mg/kg). Twenty rats (10 M, 10 F) completed enhancement testing with nicotine before d-amphetamine. The other 20 rats (10 M, 10 F) completed testing with d-amphetamine before nicotine. Following these phases, rats were then given two pre-session injections: one of d-amphetamine (Sal, 0.1, 0.3, or 0.6 mg/kg) and another of nicotine (Sal, 0.03, 0.06, 0.1, or 0.3 mg/kg). Experiencing amphetamine before nicotine increased reward-enhancing effects of nicotine. Females exhibited greater effects of d-amphetamine on reward-enhancement, with no effect of exposure order. During the interaction phase, receiving nicotine before amphetamine enhanced the interaction between nicotine and d-amphetamine for females whereas amphetamine before nicotine heightened this interaction for males. From this, prior and current amphetamine use, in addition to sex, should be considered when treating nicotine dependency and when examining factors driving poly-substance use involving nicotine and d-amphetamine.
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影响因子：
4.7
作者：
Kim, Myung N.;Jutkiewicz, Emily M.;Zhang, Minjia;Gnegy, Margaret E.
通讯作者：
Gnegy, Margaret E.
DOI：
10.1037/h0046708
发表时间：
1961-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
BARNES, GW;BARON, A
通讯作者：
BARON, A
影响因子：
1.6
作者：
Barrett, Scott T.;Geary, Trevor N.;Bevins, Rick A.
通讯作者：
Bevins, Rick A.
影响因子：
3.4
作者：
Chaudhri, Nadia;Caggiula, Anthony R.;Sved, Alan F.
通讯作者：
Sved, Alan F.
影响因子：
2.7
作者：
Cassidy, Rachel N.;Dallery, Jesse
通讯作者：
Dallery, Jesse