Continuous multiplexed population representations of task context in the mouse primary visual cortex.
Continuous multiplexed population representations of task context in the mouse primary visual cortex.
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DOI：
10.1038/s41467-023-42441-w
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发表时间：
2023-10-21
影响因子：
16.6
通讯作者：
Orban, Gergo
中科院分区：
文献类型：
--
作者：
Hajnal, Marton Albert;Tran, Duy;Einstein, Michael;Martelo, Mauricio Vallejo;Safaryan, Karen;Polack, Pierre-Olivier;Golshani, Peyman;Orban, Gergo
有效的任务执行需要多个任务相关变量的表示，这些变量决定了刺激如何导致正确的反应。甚至初级视觉皮层（V1）也代表了其他与任务相关的变量，如期望、选择和背景。然而，目前还不清楚V1如何灵活地适应这些变量，而不干扰视觉表示。我们在上下文切换跨模态决策任务上训练小鼠，其中性能取决于推断任务上下文。我们发现，出现在V1的上下文信号是行为相关的，因为它与性能强烈共变，独立于运动。重要的是，通过将视觉和上下文信号复用到正交子空间中，该信号被整合到V1表示中。此外，听觉和选择信号也被复用，因为这些信号与上下文表示正交。因此，多路复用允许V1将视觉输入与其他感觉模态和认知变量相结合，以避免干扰视觉表示，同时确保维护任务相关变量。感觉皮层主要表现为代表环境刺激。在这里，作者发现，视觉皮层活动的几何形状允许刺激和任务上下文的并行表示的格式，防止干扰。
Effective task execution requires the representation of multiple task-related variables that determine how stimuli lead to correct responses. Even the primary visual cortex (V1) represents other task-related variables such as expectations, choice, and context. However, it is unclear how V1 can flexibly accommodate these variables without interfering with visual representations. We trained mice on a context-switching cross-modal decision task, where performance depends on inferring task context. We found that the context signal that emerged in V1 was behaviorally relevant as it strongly covaried with performance, independent from movement. Importantly, this signal was integrated into V1 representation by multiplexing visual and context signals into orthogonal subspaces. In addition, auditory and choice signals were also multiplexed as these signals were orthogonal to the context representation. Thus, multiplexing allows V1 to integrate visual inputs with other sensory modalities and cognitive variables to avoid interference with the visual representation while ensuring the maintenance of task-relevant variables. Sensory cortex has been primarily shown to represent environmental stimuli. Here, the authors find that the geometry of visual cortical activity permits the parallel representation of stimuli and task context in a format that prevents interference.
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