Early gray-matter and white-matter concentration in infancy predict later language skills: a whole brain voxel-based morphometry study.
Early gray-matter and white-matter concentration in infancy predict later language skills: a whole brain voxel-based morphometry study.
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DOI：
10.1016/j.bandl.2012.10.007
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发表时间：
2013-01
影响因子：
2.5
通讯作者：
Kuhl, Patricia K.
中科院分区：
文献类型：
--
作者：
Can, Dilara Deniz;Richards, Todd;Kuhl, Patricia K.
关键词：
对19名7个月大的婴儿进行了磁共振成像（MRI）脑部扫描。在12个月时评估表达和接受语言表现。基于体素的形态测定法（VBM）确定了7个月时灰质和白质浓度与12个月时儿童语言分数显著相关的大脑区域。右侧小脑的早期灰质浓度、右侧小脑的早期白质浓度和左侧内囊后肢（PLIC）/大脑脚的早期白质浓度与婴儿12个月时的接受性语言能力呈正相关。右侧海马体的早期灰质浓度与婴儿12个月时的语言表达能力呈正相关。我们的研究结果表明，小脑，PLIC/大脑脚，和海马可能与早期语言的发展。这些结构预测和婴儿的语言功能之间的潜在联系进行了讨论。
Magnetic Resonance Imaging (MRI) brain scans were obtained from 19 infants at 7 months. Expressive and receptive language performance was assessed at 12 months. Voxel-based morphometry (VBM) identified brain regions where gray-matter and white-matter concentrations at 7 months correlated significantly with children’s language scores at 12 months. Early gray-matter concentration in the right cerebellum, early white-matter concentration in the right cerebellum, and early white-matter concentration in the left posterior limb of the internal capsule (PLIC)/cerebral peduncle were positively and strongly associated with infants’ receptive language ability at 12 months. Early gray-matter concentration in the right hippocampus was positively and strongly correlated with infants’ expressive language ability at 12 months. Our results suggest that the cerebellum, PLIC/cerebral peduncle, and the hippocampus may be associated with early language development. Potential links between these structural predictors and infants’ linguistic functions are discussed.
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影响因子：
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