Investigating white matter development in infancy and early childhood using myelin water faction and relaxation time mapping.
Investigating white matter development in infancy and early childhood using myelin water faction and relaxation time mapping.
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DOI：
10.1016/j.neuroimage.2012.07.037
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发表时间：
2012-11-15
期刊：
影响因子：
5.7
通讯作者：
Jerskey, Beth A.
中科院分区：
文献类型：
--
作者：
Deoni, Sean C. L.;Dean, Douglas C., III;O'Muircheartaigh, Jonathan;Dirks, Holly;Jerskey, Beth A.
关键词：
有髓鞘白色物质的发育对于正常的神经发育是必不可少的，建立和介导整个大脑的快速通信通路。这些通路促进了高阶行为和认知功能所需的同步通信。由异常的白色物质和髓鞘发育引起的神经信息传递（或"断开"）的改变可能是许多神经发育性精神障碍的基础。尽管髓磷脂发挥着重要作用，但很少有成像研究专门研究其在婴儿早期和儿童期的成熟。因此，对行为和认知功能的进化与支持神经系统的髓鞘形成之间的关系的直接调查很少。此外，在不了解"规范"发育时程的情况下，与发育障碍相关的早期异常的识别仍然具有挑战性。在这项工作中，我们研究了使用纵向（T1）和横向（T2）弛豫时间映射，和髓鞘水分数（MWF）成像调查白色物质和髓鞘发育的153名健康男性和女性儿童，3个月至60个月的年龄。使用DESPOT和mcDESPOT成像技术开发了优化的年龄特定采集协议;确定了额叶、颞叶、枕叶、顶叶和小脑白色物质以及胼胝体的胼胝体、体部和压部的平均T1、T2和MWF轨迹。MWF结果提供了一个与先前髓鞘形成的组织学研究一致的时空模式。T1、T2和MWF测量的比较表明，对与神经发育相关的组织变化的敏感性不同，每种测量都提供不同但互补的信息。研究儿童时期大脑T1、T2和髓鞘水分数的发育情况;建立非镇静婴儿和幼儿成像方案;研究生命最初5年的区域T1、T2和MWF轨迹;比较不同年龄段的T1、T2和MWF估计值
The elaboration of the myelinated white matter is essential for normal neurodevelopment, establishing and mediating rapid communication pathways throughout the brain. These pathways facilitate the synchronized communication required for higher order behavioral and cognitive functioning. Altered neural messaging (or ‘disconnectivity’) arising from abnormal white matter and myelin development may underlie a number of neurodevelopmental psychiatric disorders. Despite the vital role myelin plays, few imaging studies have specifically examined its maturation throughout early infancy and childhood. Thus, direct investigations of the relationship(s) between evolving behavioral and cognitive functions and the myelination of the supporting neural systems have been sparse. Further, without knowledge of the ‘normative’ developmental time-course, identification of early abnormalities associated with developmental disorders remains challenging. In this work, we examined the use of longitudinal (T1) and transverse (T2) relaxation time mapping, and myelin water fraction (MWF) imaging to investigate white matter and myelin development in 153 healthy male and female children, 3 months through 60 months in age. Optimized age-specific acquisition protocols were developed using the DESPOT and mcDESPOT imaging techniques; and mean T1, T2 and MWF trajectories were determined for frontal, temporal, occipital, parietal and cerebellar white matter, and genu, body and splenium of the corpus callosum. MWF results provided a spatio-temporal pattern in-line with prior histological studies of myelination. Comparison of T1, T2 and MWF measurements demonstrates dissimilar sensitivity to tissue changes associated with neurodevelopment, with each providing differential but complementary information. ► Investigate brain T1, T2 and myelin water fraction development across childhood ► Establish protocols for non-sedated infant and toddler imaging ► Regional T1, T2 and MWF trajectories spanning the first 5 years of life ► Comparison between, T1, T2 and MWF estimates across the age range
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影响因子：
16.2
作者：
Giedd, Jay N.;Rapoport, Judith L.
通讯作者：
Rapoport, Judith L.
影响因子：
3.3
作者：
Deoni, Sean C. L.;Rutt, Brian K.;Jones, Derek K.
通讯作者：
Jones, Derek K.
DOI：
10.1097/00004583-200109000-00009
发表时间：
2001-09-01
影响因子：
13.3
作者：
Durston, S;Pol, HEH;van Engeland, H
通讯作者：
van Engeland, H
影响因子：
4.2
作者：
Bartzokis, George;Lu, Po H.;Tingus, Kathleen;Mendez, Mario F.;Richard, Aurore;Peters, Douglas G.;Oluwadara, Bolanle;Barrall, Katherine A.;Finn, J. Paul;Villablanca, Pablo;Thompson, Paul M.;Mintz, Jim
通讯作者：
Mintz, Jim
影响因子：
5.7
作者：
Fonov V;Evans AC;Botteron K;Almli CR;McKinstry RC;Collins DL;Brain Development Cooperative Group
通讯作者：
Brain Development Cooperative Group