Identification of Pulmonary Hypertension Animal Models Using a New Evolutionary Machine Learning Framework Based on Blood Routine Indicators.
Identification of Pulmonary Hypertension Animal Models Using a New Evolutionary Machine Learning Framework Based on Blood Routine Indicators.
复制标题
使用基于血常规指标的新型进化机器学习框架识别肺动脉高压动物模型
DOI:
10.1007/s42235-022-00292-z
复制
发表时间:
2023
影响因子:
4
通讯作者:
Wu, Peiliang
中科院分区:
文献类型:
--
作者:
Hu, Jiao;Lv, Shushu;Zhou, Tao;Chen, Huiling;Xiao, Lei;Huang, Xiaoying;Wang, Liangxing;Wu, Peiliang
Pulmonary Hypertension (PH) is a global health problem that affects about 1% of the global population. Animal models of PH play a vital role in unraveling the pathophysiological mechanisms of the disease. The present study proposes a Kernel Extreme Learning Machine (KELM) model based on an improved Whale Optimization Algorithm (WOA) for predicting PH mouse models. The experimental results showed that the selected blood indicators, including Haemoglobin (HGB), Hematocrit (HCT), Mean, Platelet Volume (MPV), Platelet distribution width (PDW), and Platelet–Large Cell Ratio (P-LCR), were essential for identifying PH mouse models using the feature selection method proposed in this paper. Remarkably, the method achieved 100.0% accuracy and 100.0% specificity in classification, demonstrating that our method has great potential to be used for evaluating and identifying mouse PH models.
登录
查看更多内容
影响因子:
8.5
作者:
Ayyoubzadeh, Seyed Mohammad;Ayyoubzadeh, Seyed Mehdi;Kalhori, Sharareh R. Niakan
通讯作者:
Kalhori, Sharareh R. Niakan
影响因子:
4.4
作者:
Boos, Christopher J.;Beevers, Gareth D.;Lip, Gregory Y. H.
通讯作者:
Lip, Gregory Y. H.
影响因子:
14.3
作者:
Chen, Wei-Neng;Zhang, Jun;Shi, Yu-Hui
通讯作者:
Shi, Yu-Hui
影响因子:
1.6
作者:
Arslan, Derya;Cimen, Derya;Oran, Bulent
通讯作者:
Oran, Bulent
影响因子:
37.8
作者:
Chen J;Sysol JR;Singla S;Zhao S;Yamamura A;Valdez-Jasso D;Abbasi T;Shioura KM;Sahni S;Reddy V;Sridhar A;Gao H;Torres J;Camp SM;Tang H;Ye SQ;Comhair S;Dweik R;Hassoun P;Yuan JX;Garcia JGN;Machado RF
通讯作者:
Machado RF