Human cytomegalovirus glycoprotein B genotypes in renal transplant recipients
Human cytomegalovirus glycoprotein B genotypes in renal transplant recipients
复制标题
肾移植受者中人巨细胞病毒糖蛋白B基因型
DOI：
--
复制
发表时间：
1996
影响因子：
12.7
通讯作者：
D. von Laer
中科院分区：
文献类型：
--
作者：
C. Vogelberg;U. Meyer;F. Hufert;G. Kirste;D. von Laer
根据糖蛋白B（gB）基因的序列变异，人巨细胞病毒（HCMV）毒株可分为4种gB基因型。在先前的骨髓移植受者研究中，gB 1型感染比gB 2、3或4型感染与更有利的临床结局相关。用PCR和限制性内切酶分析法对60例肾移植患者和47例骨髓移植患者的gB型进行了检测。患者标本中的所有HCMV变异体都可归属于先前描述的四种gB类型之一。从39例患者中获得的两个或多个标本进行了分析，在这些患者中的31 gB型是相同的，在所有样本。gB型与肾移植受者的临床结局或病毒血症水平无关。© 1996 Wiley利斯公司
Based on sequence variation of the glycoprotein B (gB) gene, human cytomegalovirus (HCMV) strains can be classified into four gB genotypes. In a previous study of bone marrow transplant recipients, infection with the gB type 1 correlated with a more favorable clinical outcome than infection with the gB types 2, 3, or 4. The gB type was determined in 60 renal transplant and in 47 bone marrow transplant recipients using PCR and restriction analysis. All HCMV variants in patient specimens could be assigned to one of the four previously described gB types. Two or more specimens obtained from 39 patients were analysed; in 31 of these patients the gB type was the same in all samples. The gB type did not correlate with the clinical outcome or the level of viremia in renal transplant recipients. © 1996 Wiley‐Liss, Inc.
影响因子：
3.7
作者：
NAVARRO, D;PAZ, P;PEREIRA, L
通讯作者：
PEREIRA, L
影响因子：
6.4
作者：
FRIES, BC;CHOU, SW;TOROKSTORB, B
通讯作者：
TOROKSTORB, B