The HTLV-1-encoded protein HBZ directly inhibits the acetyl transferase activity of p300/CBP.
The HTLV-1-encoded protein HBZ directly inhibits the acetyl transferase activity of p300/CBP.
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DOI：
10.1093/nar/gks244
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发表时间：
2012-07
影响因子：
14.9
通讯作者：
Lemasson I
中科院分区：
文献类型：
--
作者：
Wurm T;Wright DG;Polakowski N;Mesnard JM;Lemasson I
The homologous cellular coactivators p300 and CBP contain intrinsic lysine acetyl transferase (termed HAT) activity. This activity is responsible for acetylation of several sites on the histones as well as modification of transcription factors. In a previous study, we found that HBZ, encoded by the Human T-cell Leukemia Virus type 1 (HTLV-1), binds to multiple domains of p300/CBP, including the HAT domain. In this study, we found that HBZ inhibits the HAT activity of p300/CBP through the bZIP domain of the viral protein. This effect correlated with a reduction of H3K18 acetylation, a specific target of p300/CBP, in cells expressing HBZ. Interestingly, lower levels of H3K18 acetylation were detected in HTLV-1 infected cells compared to non-infected cells. The inhibitory effect of HBZ was not limited to histones, as HBZ also inhibited acetylation of the NF-κB subunit, p65, and the tumor suppressor, p53. Recent studies reported that mutations in the HAT domain of p300/CBP that cause a defect in acetylation are found in certain types of leukemia. These observations suggest that inhibition of the HAT activity by HBZ is important for the development of adult T-cell leukemia associated with HTLV-1 infection.
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影响因子：
4
作者：
Brownell, JE;Allis, CD
通讯作者：
Allis, CD
影响因子：
4.8
作者：
Basbous, J;Arpin, C;Mesnard, JM
通讯作者：
Mesnard, JM
DOI：
10.1073/pnas.0900383106
发表时间：
2009-03-03
影响因子：
11.1
作者：
Burge, Sarah;Teufel, Daniel P.;Fersht, Alan R.
通讯作者：
Fersht, Alan R.
影响因子：
64.5
作者：
Chakravarti, D;Ogryzko, V;Evans, RM
通讯作者：
Evans, RM
影响因子：
4.8
作者：
Balasubramanyam, K;Varier, RA;Kundu, TK
通讯作者：
Kundu, TK