Signaling pathways involved in environmental sensing in Trypanosoma cruzi.
Signaling pathways involved in environmental sensing in Trypanosoma cruzi.
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DOI：
10.1111/mmi.14621
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发表时间：
2021-05
影响因子：
3.6
通讯作者：
Docampo R
中科院分区：
文献类型：
--
作者：
Lander N;Chiurillo MA;Docampo R
克氏锥虫是一种单细胞寄生虫，也是恰加斯病的病原体。这种寄生虫具有在哺乳动物和昆虫宿主之间交替的双遗传生命周期，它面临着必须适应才能生存的各种环境条件。对这些变化的适应是通过协调细胞对新环境设置的反应的信号通路介导的。主要的环境变化包括温度、营养物质可用性、离子组成、pH、渗透压、氧化应激、与宿主细胞和组织的接触、宿主免疫反应和细胞内生命。近年来，一些可能参与这些变化反应的信号通路和第二信使已被阐明，并将成为本次综述的主题。克氏锥虫是恰加斯病的病原体，它需要适应多种环境条件。我们在这里总结了参与这些变化反应的信号通路和第二信使。
Trypanosoma cruzi is a unicellular parasite and the etiologic agent of Chagas disease. The parasite has a digenetic life cycle alternating between mammalian and insect hosts, where it faces a variety of environmental conditions to which it must adapt in order to survive. The adaptation to these changes is mediated by signaling pathways that coordinate the cellular responses to the new environmental settings. Major environmental changes include temperature, nutrient availability, ionic composition, pH, osmolarity, oxidative stress, contact with host cells and tissues, host immune response, and intracellular life. Some of the signaling pathways and second messengers potentially involved in the response to these changes have been elucidated in recent years and will be the subject of this review. Trypanosoma cruzi, the etiologic agent of Chagas disease, faces a variety of environmental conditions to which it adapts. We summarize here the signaling pathways and second messengers involved in the response to these changes.
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影响因子：
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作者：
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通讯作者：
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