Leydig cells: From stem cells to aging.
Leydig cells: From stem cells to aging.
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DOI：
10.1016/j.mce.2009.01.023
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发表时间：
2009-07-10
影响因子：
4.1
通讯作者：
Zirkin BR
中科院分区：
文献类型：
--
作者：
Chen H;Ge RS;Zirkin BR
睾丸间质细胞是睾丸中产生睾丸激素的细胞。成年睾丸间质细胞群最终由存在于新生儿睾丸间质室的未分化间充质样干细胞发育而来。成人间质细胞的发育有四个不同的阶段：干细胞间质细胞、祖间质细胞、未成熟间质细胞和成体间质细胞。间质干细胞是未分化的细胞，能够无限自我更新、分化和补充间质细胞生态位。前体间质细胞来源于干细胞间质细胞。这些梭形细胞是促黄体生成素（LH）受体阳性，有丝分裂活性高，产生少量睾酮，而是睾酮代谢物。祖间质细胞产生未成熟的间质细胞，它们呈圆形，含有大量光滑的内质网，并产生一些睾酮，但也产生非常高水平的睾酮代谢物。这些细胞的一次分裂产生成年间质细胞，这是一种最终分化的细胞，能产生高水平的睾丸激素。随着男性年龄的增长，血清睾酮水平下降，这与身体成分、能量水平、肌肉力量、身体、性功能和认知功能以及情绪的变化有关。褐挪威大鼠被广泛用作雄性生殖衰老的模型，其血清睾酮与年龄相关的降低是由于衰老的间质细胞在LH刺激下产生睾酮的能力显著下降。本文就间质细胞的发育和衰老作一综述。此外，讨论了睾酮合成随年龄增长而下降的分子机制。
Leydig cells are the testosterone-producing cells of the testis. The adult Leydig cell population ultimately develops from undifferentiated mesenchymal-like stem cells present in the interstitial compartment of the neonatal testis. Four distinct stages of adult Leydig cell development have been identified and characterized: stem Leydig cells, progenitor Leydig cells, immature Leydig cells and adult Leydig cells. The stem Leydig cells are undifferentiated cells that are capable of indefinite self-renewal, differentiation, and replenishment of the Leydig cell niche. Progenitor Leydig cells are derived from the stem Leydig cells. These spindle-shaped cells are luteinizing hormone (LH) receptor positive, have high mitotic activity, and produce little testosterone but rather testosterone metabolites. The progenitor Leydig cells give rise to immature Leydig cells which are round, contain large amounts of smooth endoplasmic reticulum, and produce some testosterone but also very high levels of testosterone metabolites. A single division of these cells produces adult Leydig cells, which are terminally differentiated cells that produce high levels of testosterone. As men age, serum testosterone levels decline, and this is associated with alterations in body composition, energy level, muscle strength, physical, sexual and cognitive functions, and mood. In the Brown Norway rat, used extensively as a model for male reproductive aging, age-related reductions in serum testosterone result from significant decline in the ability of aged Leydig cells to produce testosterone in response to LH stimulation. This review describes Leydig cell development and aging. Additionally, the molecular mechanisms by which testosterone synthesis declines with aging are discussed.
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影响因子：
4.8
作者：
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通讯作者：
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发表时间：
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影响因子：
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通讯作者：
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