Hepatic venular resistance responses to norepinephrine, isoproterenol, adenosine, histamine, and ACh in rabbits.
Hepatic venular resistance responses to norepinephrine, isoproterenol, adenosine, histamine, and ACh in rabbits.
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兔肝小静脉对去甲肾上腺素、异丙肾上腺素、腺苷、组胺和乙酰胆碱的抵抗反应。
DOI：
10.1152/ajpheart.1998.274.3.h777
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Maass-Moreno,R
中科院分区：
文献类型：
--
作者：
Rothe,CF;Maass-Moreno,R
通过肝小静脉-下腔静脉压力梯度[49 ± 15（SD）μm血管中的伺服零位微量移液器]和总肝血流量（环绕肝动脉和门静脉的超声探头）估计兔肝静脉阻力的变化。肝体积的变化，因此血管电容，估计从肝叶厚度的措施。去甲肾上腺素（NE）、异丙肾上腺素（Iso）、腺苷（Ado）、组胺（Hist）或乙酰胆碱（ACh）以恒定速率注入门静脉5 min。NE、Hist和Ado增加肝小静脉压力，但只有NE和Hist显著增加肝小静脉阻力。去甲肾上腺素使肝脏厚度减小，而Hist和Ado使肝脏肿胀。去甲肾上腺素（NE）和腺苷（Ado）可增加肝血流量，而乙酰胆碱（ACh）可减少肝血流量。在与NE相似的剂量下，门静脉内输注Iso对肝血管的影响不显著。我们的结论是，NE作用于所有的肝脏微血管，增加阻力和积极减少血管体积。Hist通过增加流出阻力被动诱导充血，而Ado观察到的肝脏充血与血流量增加被动相关。ACh收缩门静脉，但不改变肝脏体积。
Changes in hepatic venous resistance were estimated in rabbits from the hepatic venular-inferior vena caval pressure gradient [servo-null micropipettes in 49 ± 15 (SD) μm vessels] and the total hepatic blood flow (ultrasound probe encircling the hepatic artery and the portal vein). Changes in liver volume, and thus vascular capacitance, were estimated from measures of the liver lobe thickness. Norepinephrine (NE), isoproterenol (Iso), adenosine (Ado), histamine (Hist), or acetylcholine (ACh) was infused into the portal vein at a constant rate for 5 min. NE, Hist, and Ado increased hepatic venular pressure, but only NE and Hist significantly increased hepatic venular resistance. NE reduced the liver thickness, but Hist and Ado caused engorgement. Hepatic blood flow was increased by NE and Ado and decreased by ACh. The influence of intraportal vein infusion of Iso on the liver vasculature, at doses similar to that of NE, was insignificant. We conclude that NE acted on all the hepatic microvasculature, increasing resistance and actively decreasing vascular volume. Hist passively induced engorgement by increasing outflow resistance, whereas the liver engorgement seen with Ado was passively related to the increased blood flow. ACh constricted the portal venules but did not change the liver volume.
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影响因子：
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作者：
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DOI：
10.1073/pnas.83.23.8829
发表时间：
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影响因子：
11.1
作者：
Pakula,AA;Young,VB;Sauer,RT
通讯作者：
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影响因子：
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作者：
Zoller,MJ;Smith,M
通讯作者：
Smith,M
影响因子：
5.6
作者：
WEAVER, LH;MATTHEWS, BW
通讯作者：
MATTHEWS, BW