Cytochrome P450 arachidonic acid metabolites modulate renal tubular function.

Cytochrome P450 arachidonic acid metabolites modulate renal tubular function.
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细胞色素 P450 花生四烯酸代谢物调节肾小管功能。

DOI:
10.1007/978-1-4419-9194-2_13
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发表时间:
2003
影响因子:
--
通讯作者:
McGiff,JohnC
McGiff,JohnC
中科院分区:
医学4区
文献类型:
--
作者:
Carroll,MaireadA;Ferreri,NicholasR;Escalante,BrunoA;Oyekan,AdebayoO;McGiff,JohnC

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Nephron function is segmented. Each segment has characteristic transport mechanisms and individual eicosanoid profiles [1,[2]]. Mapping the distribution of AA metabolizing enzymes within the nephron is essential to understanding the contribution of eicosanoids to excretory function. The study of Bonvalet et al addressed the localization of cyclooxygenase (COX) in the nephron and uncovered large segments that had negligible COX activity, particularly the proximal tubules (PT) and the thick ascending limb (TAL) [[3]], which later studies identified as segments heavily invested with cytochrome monooxygenase (CYP450) activity [[4],[5]].
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