Malnutrition and immune cell subsets in children undergoing kidney transplantation.
Malnutrition and immune cell subsets in children undergoing kidney transplantation.
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DOI：
10.1111/petr.14371
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发表时间：
2022-12
影响因子：
1.3
通讯作者：
Chambers, Eileen T.
中科院分区：
文献类型：
--
作者：
Shaw, Brian, I;Lee, Hui-Jie;Ettenger, Robert;Grimm, Paul;Reed, Elaine F.;Sarwal, Minnie;Stempora, Linda;Warshaw, Barry;Zhao, Congwen;Martinez, Olivia M.;MacIver, Nancie J.;Kirk, Allan D.;Chambers, Eileen T.
儿童营养不良，包括肥胖和营养不足的流行率正在上升，在接受肾脏替代治疗的儿童中很常见。营养不良对移植前免疫系统的影响以及小儿免疫系统如何对免疫抑制和同种异体移植的损伤作出反应尚不清楚。我们研究了营养状况与移植后结果的关系，并对来自儿科移植免疫发育（IMPACT）研究的儿童的外周免疫细胞表型进行了表征。来自IMPACT研究的98名患者被分类为肥胖、营养不良或基于正常营养的移植前测量。使用Gray检验和Fine-Gray子分布风险模型比较营养组之间移植后1年感染和同种免疫结局的发生率。采用Kaplan-Meier法估计无事件生存期，并进行组间比较。使用解释重复测量之间相关性的广义估计方程确定营养组之间随时间推移的免疫细胞亚群差异。我们没有观察到营养状况与感染或同种异体免疫事件或移植后无事件生存率相关。我们证明，肥胖儿童与营养不良和正常营养的儿童相比，即使在控制免疫抑制的情况下，也有不同的T和B细胞特征。肥胖儿童在移植后9个月的CD 8 T细胞频率较低（p<0.001），在移植后12个月的CD 4 CD 57 + PD 1- T细胞频率较高，CD 57-PD 1 + CD 8和CD 57-PD 1-CD 8 T细胞频率较低（均p<0.05）。肥胖儿童有不同的免疫表型，可能会影响免疫抑制的剪裁。
Malnutrition, including obesity and undernutrition, among children is increasing in prevalence and is common among children on renal replacement therapy. The effect of malnutrition on the pre-transplant immune system and how the pediatric immune system responds to the insult of both immunosuppression and allotransplantation is unknown. We examined the relationship of nutritional status with post-transplant outcomes and characterized the peripheral immune cell phenotypes of children from the Immune Development of Pediatric Transplant (IMPACT) study. Ninety-eight patients from the IMPACT study were classified as having obesity, undernutrition, or normal nutrition-based pre-transplant measurements. Incidence of infectious and alloimmune outcomes at 1-year post-transplantation were compared between nutritional groups using Gray’s test and Fine-Gray subdistribution hazards model. Event-free survival was estimated by Kaplan-Meier method and compared between groups. Differences in immune cell subsets between nutritional groups over time were determined using generalized estimating equations accounting for the correlation between repeated measurements. We did not observe that nutritional status was associated with infectious or alloimmune events or event-free survival post-transplant. We demonstrated that children with obesity had distinct T and B cell signatures relative to those with undernutrition and normal nutrition, even when controlling for immunosuppression. Children with obesity had a lower frequency of CD8 Tnaive cells 9-month post-transplant (p<0.001), a higher frequency of CD4 CD57+PD1- T cells, and lower frequencies of CD57-PD1+ CD8 and CD57-PD1- CD8 T cells at 12-month transplant (p<0.05 for all). Children with obesity have distinct immunophenotypes that may influence the tailoring of immunosuppression.
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抗Belatacept的排斥反应与CD28（+）内存CD8 T细胞有关。
DOI：
10.1111/ajt.14349
发表时间：
2017-09
期刊：
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
影响因子：
--
作者：
Mathews DV;Wakwe WC;Kim SC;Lowe MC;Breeden C;Roberts ME;Farris AB;Strobert EA;Jenkins JB;Larsen CP;Ford ML;Townsend R;Adams AB
通讯作者：
Adams AB
DOI：
10.1111/ajt.13613
发表时间：
2016-04
期刊：
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
影响因子：
--
作者：
Espinosa J;Herr F;Tharp G;Bosinger S;Song M;Farris AB 3rd;George R;Cheeseman J;Stempora L;Townsend R;Durrbach A;Kirk AD
通讯作者：
Kirk AD
影响因子：
0.9
作者：
Grosso, G.;Corona, D.;Veroux, M.
通讯作者：
Veroux, M.
影响因子：
3
作者：
Denburg, Michelle R.;Pradhan, Madhura;Leonard, Mary B.
通讯作者：
Leonard, Mary B.
影响因子：
6.3
作者：
Diamanti, Antonella;Cereda, Emanuele;Raponi, Massimiliano
通讯作者：
Raponi, Massimiliano