Growth Hormone (GH) and Cardiovascular System.
Growth Hormone (GH) and Cardiovascular System.
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DOI：
10.3390/ijms19010290
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发表时间：
2018-01-18
影响因子：
5.6
通讯作者：
Devesa J
中科院分区：
文献类型：
--
作者：
Caicedo D;Díaz O;Devesa P;Devesa J
本文综述了生长激素（GH）对心血管系统的积极作用。我们分析了为什么血管内皮是一个真实的内分泌腺，其炎症是发展动脉粥样硬化的第一步，以及GH作用于血管改善氧化应激失衡和内皮功能障碍的机制。我们还报告了生长激素如何作用于冠状动脉疾病和心力衰竭，以及外周动脉疾病，诱导新血管形成过程，最终增加缺血组织的血流。我们包括一些初步的数据，从试验中，生长激素或安慰剂给予老年人患有严重的肢体缺血，显示一些好处的激素对炎症的血浆标志物，和安全的生长激素管理在短时间内，即使在糖尿病患者。我们还分析了Klotho如何与GH密切相关，在从受损的血管内皮释放后，诱导垂体分泌GH，最有可能修复缺血组织中的损伤。我们还展示了生长激素如何通过增加血流量和一些神经营养因子和生长因子来帮助伤口愈合。总之，我们假设短期GH给药可能有助于治疗心血管疾病。
This review describes the positive effects of growth hormone (GH) on the cardiovascular system. We analyze why the vascular endothelium is a real internal secretion gland, whose inflammation is the first step for developing atherosclerosis, as well as the mechanisms by which GH acts on vessels improving oxidative stress imbalance and endothelial dysfunction. We also report how GH acts on coronary arterial disease and heart failure, and on peripheral arterial disease, inducing a neovascularization process that finally increases flow in ischemic tissues. We include some preliminary data from a trial in which GH or placebo is given to elderly people suffering from critical limb ischemia, showing some of the benefits of the hormone on plasma markers of inflammation, and the safety of GH administration during short periods of time, even in diabetic patients. We also analyze how Klotho is strongly related to GH, inducing, after being released from the damaged vascular endothelium, the pituitary secretion of GH, most likely to repair the injury in the ischemic tissues. We also show how GH can help during wound healing by increasing the blood flow and some neurotrophic and growth factors. In summary, we postulate that short-term GH administration could be useful to treat cardiovascular diseases.
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影响因子：
1.9
作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1161/01.atv.0000047448.76485.b8
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影响因子：
8.7
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作者：
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通讯作者：
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