The effect of diabetes mellitus on chronic rhinosinusitis and sinus surgery outcome.
The effect of diabetes mellitus on chronic rhinosinusitis and sinus surgery outcome.
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DOI：
10.1002/alr.21269
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发表时间：
2014-04
影响因子：
6.4
通讯作者：
Palmer, James N.
中科院分区：
文献类型：
--
作者：
Zhang, Zi;Adappa, Nithin D.;Lautenbach, Ebbing;Chiu, Alexander G.;Doghramji, Laurel;Howland, Timothy J.;Cohen, Noam A.;Palmer, James N.
糖尿病（DM）患者易感染。然而，糖尿病和慢性鼻窦炎（CRS）之间的关系尚未得到很好的研究。我们试图确定功能性内窥镜鼻窦手术（FESS）后DM对CRS培养结果和生活质量（QOL）的影响。我们进行了一项回顾性队列研究。从2007年10月1日至2011年12月31日招募了接受FESS的成人CRS患者。在FESS前收集患者人口统计学资料、合并症、药物使用、Lund-Mackay CT评分。获得术中培养。术前及术后1、3、6个月采用22项鼻腔鼻窦预后测试（SNOT-22）评分测量QOL。采用混合效应模型进行分析。在纳入的376例CRS患者中，19例患者（5.05%）患有DM。与非糖尿病患者相比，糖尿病患者更容易感染绿脓杆菌（26.32% vs 7.56%，p=0.004）和革兰氏阴性杆菌（26.32%vs.8.96%，p= 0.013），但金黄色葡萄球菌感染率无显著性差异;糖尿病患者也明显更容易患鼻息肉和胃食管反流病。此外，在调整CRS的所有其他风险因素后，DM患者术后SNOT-22评分从基线至6个月随访的改善显著低于非DM患者（调整后平均值=11.14，95% CI（0.14，22.15），p=0.047）。糖尿病患者可能容易发生革兰氏阴性细菌鼻窦感染，术后短期生活质量明显较差。CRS合并DM患者可能需要考虑特殊的术后护理
Patients with diabetes mellitus (DM) are known to be liable to infection. However, the association between diabetes and chronic rhinosinusitis (CRS) has not been well studied. We sought to determine the effects of DM on CRS culture results and quality of life (QOL) after functional endoscopic sinus surgery (FESS). We conducted a retrospective cohort study. Adult CRS patients undergoing FESS were recruited from 10/1/2007 to 12/31/2011. Patient demographics, comorbidities, medication use, Lund-Mackay CT scores were collected prior to FESS. Intraoperative culture was obtained. Preoperative and 1-, 3- and 6-month postoperative QOL was measured by the 22 item Sinonasal Outcome Test (SNOT-22) scores. A mixed effects model was performed for analysis. Among the 376 CRS patients included, 19 patients (5.05%) had DM. Compared to non-DM patients, DM patients were significantly more likely to have Pseudomonas aeruginosa (26.32% versus 7.56%, p=0.004) and gram negative rods (26.32% vs. 8.96%, p= 0.013), but there were no significant difference in the prevalence of Staphylococcus aureus; DM patients were also significantly more likely to have nasal polyps and gastroesophageal reflux disease. Additionally, DM patients had significantly less improvement of postoperative SNOT-22 scores from baseline to 6-month follow-up than non-DM patients (adjusted mean=11.14, 95% CI (0.14, 22.15), p=0.047) after adjusting for all the other risk factors for CRS. DM patients may be prone to gram negative bacterial sinus infections, and have significantly worse short-term postoperative QOL. Special postoperative care may need to be considered in CRS patients with DM
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影响因子：
2.8
作者：
Larsen, K
通讯作者：
Larsen, K
影响因子：
2.5
作者：
Musy, PY;Kountakis, SE
通讯作者：
Kountakis, SE
DOI：
10.1177/194589240501900602
发表时间：
2005-11-01
期刊：
AMERICAN JOURNAL OF RHINOLOGY
影响因子：
--
作者：
Bhattacharyya, N
通讯作者：
Bhattacharyya, N
影响因子：
3.4
作者：
Lee SD;Keum B;Chun HJ;Bak YT
通讯作者：
Bak YT
影响因子：
2.6
作者：
Houser, Steven M.;Keen, Kevin J.
通讯作者：
Keen, Kevin J.