Gastroesophageal Reflux Disease in Type II Diabetes Mellitus With or Without Peripheral Neuropathy.
Gastroesophageal Reflux Disease in Type II Diabetes Mellitus With or Without Peripheral Neuropathy.
复制标题
DOI：
10.5056/jnm.2011.17.3.274
复制
发表时间：
2011-07
影响因子：
3.4
通讯作者：
Bak YT
中科院分区：
文献类型：
--
作者：
Lee SD;Keum B;Chun HJ;Bak YT
已知2型糖尿病（DM）患者有较高的胃食管反流病（GERD）患病率。近年来的研究表明，神经病变对II型DM的胃食管反流的发展有积极的作用，尽管其发病机制尚未完全清楚。本研究的目的是调查韩国II型糖尿病患者的神经病变是否真的促进了GERD的发展和典型的GERD症状。191名知情同意的II型糖尿病患者被纳入研究。所有患者均行肌电图检查周围神经病变的存在，面对面访谈评估其典型的GERD症状，并进行食管胃十二指肠镜检查以寻找糜烂性食管炎的存在。95例患者最终被纳入本研究，并根据有无周围神经病变进行分组。95例患者平均年龄59.3±9.1岁，DM平均病程9.3±5.9年。有周围神经病变和无周围神经病变两组的典型GERD症状相似（23.6% vs 22.8%, P = 0.921）。糜烂性食管炎在神经病变患者中的发生率高于无神经病变患者（31.5% vs 10.5%, P = 0.022）。在II型糖尿病患者中，周围神经病变是糜烂性食管炎的独立危险因素。然而，周围神经病变并没有导致典型反流症状的出现。
Patients with type II diabetes mellitus (DM) were known to have higher prevalence of gastroesophageal reflux disease (GERD). Recent studies have shown that neuropathy has positive role on the development of GERD in type II DM, although its pathogenesis has not been fully understood yet. The aim of this study was to investigate whether neuropathy really contribute to the development of GERD and typical GERD symptoms in patients with type II DM in Korea. One hundred and nineteen patients with type II DM who had given informed consents were enrolled. All patients underwent electromyography to check the presence of peripheral neuropathy, face-to-face interview to evaluate their typical GERD symptoms and esophagogastroduodenoscopy to look for the presence of erosive esophagitis. Ninety-five patients were finally included for this study and they were divided according to the presence or absence of the peripheral neuropathy. The mean age of 95 patients was 59.3 ± 9.1 years and the mean disease duration of DM was 9.3 ± 5.9 years. Typical GERD symptoms were similarly found in both groups with and without peripheral neuropathy (23.6% vs 22.8%, P = 0.921). Erosive esophagitis was more prevalent in patients with neuropathy than in those without neuropathy (31.5% vs 10.5%, P = 0.022). In patients with type II DM, peripheral neuropathy is an independent risk factor for the erosive esophagitis. However, peripheral neuropathy did not contribute to the presence of the typical GERD symptoms.
登录
查看更多内容
影响因子：
4.4
作者：
LANTING, P;FAES, TJC;VANDERVEEN, EA
通讯作者：
VANDERVEEN, EA
DOI：
10.1111/j.1440-1746.2010.06410.x
发表时间：
2011-01-01
影响因子：
4.1
作者：
Park, Sanghoon;Lee, Eun Joo;Lee, Sung Joon
通讯作者：
Lee, Sung Joon
影响因子：
--
作者：
PARKMAN, HP;SCHWARTZ, SS
通讯作者：
SCHWARTZ, SS
影响因子：
4.3
作者：
Jeong, Leong-Jo;Choi, Myung-Gyu;Chung, In-Sik
通讯作者：
Chung, In-Sik
影响因子：
1.9
作者：
Spångéus, A;El-Salhy, M;Lithner, F
通讯作者：
Lithner, F