Common variants related to serum uric acid concentrations are associated with glucose metabolism and insulin secretion in a Chinese population.
Common variants related to serum uric acid concentrations are associated with glucose metabolism and insulin secretion in a Chinese population.
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DOI：
10.1371/journal.pone.0116714
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Jia W
中科院分区：
文献类型：
--
作者：
Sun X;Zhang R;Jiang F;Tang S;Chen M;Peng D;Yan J;Wang T;Wang S;Bao Y;Hu C;Jia W
血清尿酸浓度升高是2型糖尿病（T2 D）的独立危险因素和预测因子。尿酸相关基因是否对T2 D有影响尚不清楚。我们的目的是研究尿酸相关基因对2型糖尿病风险以及葡萄糖代谢和胰岛素分泌的影响。我们从上海糖尿病研究I和II中招募了2，199名正常葡萄糖耐量受试者，从上海糖尿病研究所的住院患者数据库中招募了2，999名T2 D患者。对11个位点（PDZK 1、GCKR、LRP 2、SLC 2A 9、ABCG 2、LRRC 16 A、SLC 17 A1、SLC 17 A3、SLC 22 A11、SLC 22 A12和SF 1）或其附近的15个单核苷酸多态性（SNP）进行基因分型，并测定与尿酸和T2 D相关的血清生化指标。 SF 1 rs606458在男性和女性中均显示出与T2 D的强关联（p = 0.034和0.0008）。在男性中，LRRC 16 A与2小时胰岛素和胰岛素分泌相关（p = 0.009和0.009）。SLC 22 A11与HOMA-B和胰岛素分泌相关（p = 0.048和0.029）。SLC 2A 9 rs3775948与2小时血糖相关（p = 0.043）。在女性中，LRP 2 rs 2544390和rs 1333049显示与空腹胰岛素、HOMA-IR和胰岛素分泌相关（分别为p = 0.028、0.033和0.052以及p = 0.034、0.047和0.038）。SLC 2A 9 rs 11722228与2小时葡萄糖、2小时胰岛素和胰岛素分泌相关（分别为p = 0.024、0.049和0.049）。我们的研究结果表明，尿酸相关基因对中国人群的2型糖尿病风险、糖代谢和胰岛素分泌有影响。
Elevated serum uric acid concentration is an independent risk factor and predictor of type 2 diabetes (T2D). Whether the uric acid-associated genes have an impact on T2D remains unclear. We aimed to investigate the effects of the uric acid-associated genes on the risk of T2D as well as glucose metabolism and insulin secretion. We recruited 2,199 normal glucose tolerance subjects from the Shanghai Diabetes Study I and II and 2,999 T2D patients from the inpatient database of Shanghai Diabetes Institute. Fifteen single nucleotide polymorphisms (SNPs) mapped in or near 11 loci (PDZK1, GCKR, LRP2, SLC2A9, ABCG2, LRRC16A, SLC17A1, SLC17A3, SLC22A11, SLC22A12 and SF1) were genotyped and serum biochemical parameters related to uric acid and T2D were determined. SF1 rs606458 showed strong association to T2D in both males and females (p = 0.034 and 0.0008). In the males, LRRC16A was associated with 2-h insulin and insulin secretion (p = 0.009 and 0.009). SLC22A11 was correlated with HOMA-B and insulin secretion (p = 0.048 and 0.029). SLC2A9 rs3775948 was associated with 2-h glucose (p = 0.043). In the females, LRP2 rs2544390 and rs1333049 showed correlations with fasting insulin, HOMA-IR and insulin secretion (p = 0.028, 0.033 and 0.052 and p = 0.034, 0.047 and 0.038, respectively). SLC2A9 rs11722228 was correlated with 2-h glucose, 2-h insulin and insulin secretion (p = 0.024, 0.049 and 0.049, respectively). Our results indicated that the uric acid-associated genes have an impact on the risk of T2D, glucose metabolism and insulin secretion in a Chinese population.
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影响因子：
--
作者：
Liu WC;Hung CC;Chen SC;Lin MY;Chen LI;Hwang DY;Chang JM;Tsai JC;Chen HC;Hwang SJ
通讯作者：
Hwang SJ
影响因子：
3.7
作者：
Jia L;Xing J;Ding Y;Shen Y;Shi X;Ren W;Wan M;Guo J;Zheng S;Liu Y;Liang X;Su D
通讯作者：
Su D
影响因子：
5.8
作者：
Heni, Martin;Ketterer, Caroline;Fritsche, Andreas
通讯作者：
Fritsche, Andreas
影响因子：
3.5
作者：
Ekaratanawong, S;Anzai, N;Endou, H
通讯作者：
Endou, H
影响因子：
37.8
作者：
Duplain, H;Burcelin, R;Scherrer, U
通讯作者：
Scherrer, U