Acute asthma exacerbation due to the SARS-CoV-2 vaccine (Pfizer-BioNTech BNT162b2 messenger RNA COVID-19 vaccine [Comirnaty(Ⓡ)]).

Acute asthma exacerbation due to the SARS-CoV-2 vaccine (Pfizer-BioNTech BNT162b2 messenger RNA COVID-19 vaccine [Comirnaty(Ⓡ)]).
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DOI:
10.1016/j.ijid.2022.09.019
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发表时间:
2022-11
影响因子:
8.4
通讯作者:
Hiramatsu, Kazufumi
Hiramatsu, Kazufumi
中科院分区:
医学2区
文献类型:
--
作者:
Ando, Masaru;Satonaga, Yoshio;Takaki, Ryuichiro;Yabe, Michitoshi;Kan, Takamasa;Omote, Erika;Yamasaki, Toru;Komiya, Kosaku;Hiramatsu, Kazufumi

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The messenger RNA vaccine against SARS-CoV-2 is effective at preventing COVID-19-associated hospitalization, and the Centers for Disease Control and Prevention has recommended vaccination for all eligible individuals. We demonstrate a case involving a patient who developed a life-threatening acute asthma exacerbation after receiving their third dose of the BNT16b2 vaccine. Because eosinophilia was observed after the second inoculation, it was considered likely that the patient had been sensitized to the BNT16b2 vaccine. Theoretically, the SARS-CoV-2 vaccine could trigger the exacerbation of asthma. It should be recognized that repeated SARS-CoV-2 vaccination may be a risk factor for the acute exacerbation of asthma.
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