TGF-β in developmental and fibrogenic EMTs.
TGF-β in developmental and fibrogenic EMTs.
复制标题
DOI：
10.1016/j.semcancer.2022.09.004
复制
发表时间：
2022-11
影响因子：
14.5
通讯作者：
Massague, Joan
中科院分区：
文献类型：
--
作者：
Lee, Jun Ho;Massague, Joan
转化生长因子-β在发育和伤口愈合以及纤维化和癌症等疾病中作为上皮-间充质转化(EMT)的诱导者发挥着重要作用。在这些过程中，内皮细胞转化伴随着细胞增殖、分化、通讯和细胞外基质重塑的变化，这些变化除了转化生长因子-β外，还受到多种信号输入的调控。其中最主要的是Ras-MAPK信号，这是转化生长因子-β诱导子宫内膜转化所必需的。最近的工作阐明了转化生长因子-β-SMAD和Ras-MAPK通路在诱导胚胎、成人和癌细胞上皮细胞内皮细胞转化中协同作用的分子基础。这些研究还提供了EMT与原肠形成过程中的祖细胞分化或肿瘤转移过程中的瘤内纤维化之间的直接机制联系。这些见解阐明了转化生长因子-β驱动的子宫内膜瘤的本质，它是发育、纤维化形成和转移过程中更广泛的过程的一部分。
TGF-β plays a prominent role as an inducer of epithelial-mesenchymal transitions (EMTs) during development and wound healing and in disease conditions such as fibrosis and cancer. During these processes EMT occurs together with changes in cell proliferation, differentiation, communication, and extracellular matrix remodeling that are orchestrated by multiple signaling inputs besides TGF-β. Chief among these inputs is RAS-MAPK signaling, which is frequently required for EMT induction by TGF-β. Recent work elucidated the molecular basis for the cooperation between the TGF-β-SMAD and RAS-MAPK pathways in the induction of EMT in embryonic, adult and carcinoma epithelial cells. These studies also provided direct mechanistic links between EMT and progenitor cell differentiation during gastrulation or intra-tumoral fibrosis during cancer metastasis. These insights illuminate the nature of TGF-β driven EMTs as part of broader processes during development, fibrogenesis and metastasis.
登录
查看更多内容
影响因子：
28.2
作者：
Dominguez, Claudia X.;Mueller, Soren;Turley, Shannon J.
通讯作者：
Turley, Shannon J.
影响因子：
11.2
作者：
Deckers, M;van Dinther, M;ten Dijke, P
通讯作者：
ten Dijke, P
影响因子：
5.3
作者：
Carver, EA;Jiang, RL;Gridley, T
通讯作者：
Gridley, T
影响因子：
21.3
作者：
Batlle, E;Sancho, E;de Herreros, AG
通讯作者：
de Herreros, AG
影响因子：
4
作者：
Bolós, V;Peinado, H;Cano, A
通讯作者：
Cano, A