Accuracy of optical frequency domain imaging for evaluation of coronary adventitial vasa vasorum formation after stent implantation in pigs and humans - a validation study - .
Accuracy of optical frequency domain imaging for evaluation of coronary adventitial vasa vasorum formation after stent implantation in pigs and humans - a validation study - .
复制标题
光频域成像评估猪和人支架植入后冠状动脉外膜血管滋养管形成的准确性——一项验证研究。
作者：
K. Nishimiya;Y. Matsumoto;Hironori Uzuka;K. Oyama;A. Tanaka;A. Taruya;Tsuyoshi Ogata;Michinori Hirano;Tomohiko Shindo;K. Hanawa;Y. Hasebe;K. Hao;R. Tsuburaya;J. Takahashi;S. Miyata;K. Ito;T. Akasaka;H. Shimokawa
背景
冠状动脉外膜含有多种成分，如炎性细胞和血管（VV）。外膜VV作为炎症的由外向内供应途径启动冠状动脉疾病的发展。我们最近已经证明，药物洗脱支架植入导致VV形成的增强，延伸到猪冠状动脉中的支架边缘，并且光频域成像（OFDI）能够在体内可视化人体VV。然而，对外直接投资是否能够精确测量猪和人的VV形成仍有待充分验证。
方法和结果
在猪的方案中，共将6个裸金属支架和12个药物洗脱支架植入冠状动脉，并在1个月后，通过对外直接投资对植入支架的冠状动脉进行体外成像。对外直接投资数据，包括测量的VV面积在支架边缘部分进行了比较与组织学数据。OFDI上的VV面积与组织学上的VV面积呈显著正相关（R=0.91，P<0.01）。在人体实验中，对外直接投资使得能够测量体内冠状动脉支架植入后支架边缘的VV面积。
结论
这些结果提供了第一个直接证据，表明对外直接投资能够精确测量猪和人冠状动脉支架植入后的VV面积。
BACKGROUND
Coronary adventitia harbors a wide variety of components, such as inflammatory cells and vasa vasorum (VV). Adventitial VV initiates the development of coronary artery diseases as an outside-in supply route of inflammation. We have recently demonstrated that drug-eluting stent implantation causes the enhancement of VV formation, with extending to the stent edges in the porcine coronary arteries, and also that optical frequency domain imaging (OFDI) is capable of visualizing VV in humans in vivo. However, it remains to be fully validated whether OFDI enables the precise measurement of VV formation in pigs and humans.
METHODS AND RESULTS
In the pig protocol, a total of 6 bare-metal stents and 12 drug-eluting stents were implanted into the coronary arteries, and at 1 month, the stented coronary arteries were imaged by OFDI ex vivo. OFDI data including the measurement of VV area at the stent edge portions were compared with histological data. There was a significant positive correlation between VV area on OFDI and that on histology (R=0.91, P<0.01). In the human protocol, OFDI enabled the measurement of the VV area at the stent edges after coronary stent implantation in vivo.
CONCLUSIONS
These results provide the first direct evidence that OFDI enables the precise measurement of the VV area in coronary arteries after stent implantation in pigs and humans.
影响因子：
10.8
作者：
Herrmann, J;Lerman, LO;Lerman, A
通讯作者：
Lerman, A
DOI：
10.1016/j.jcmg.2009.10.009
发表时间：
2010-01
期刊：
JACC. Cardiovascular imaging
影响因子：
--
作者：
Gössl M;Versari D;Hildebrandt HA;Bajanowski T;Sangiorgi G;Erbel R;Ritman EL;Lerman LO;Lerman A
通讯作者：
Lerman A