Oral administration of royal jelly restores tear secretion capacity in rat blink-suppressed dry eye model by modulating lacrimal gland function.
Oral administration of royal jelly restores tear secretion capacity in rat blink-suppressed dry eye model by modulating lacrimal gland function.
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DOI：
10.1371/journal.pone.0106338
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Tsubota K
中科院分区：
文献类型：
--
作者：
Imada T;Nakamura S;Kitamura N;Shibuya I;Tsubota K
泪液由泪腺（LG）分泌，这种功能障碍会导致干眼症，导致眼部不适和视力障碍。蜂蜜蜂产品作为日常生活和医药中的营养来源；然而，人们对它们对干眼症的影响知之甚少。本研究的目的是研究蜜蜂产品对干眼症泪液分泌能力的影响。我们从市售的蜜蜂产品中选择原蜜、蜂胶、蜂王浆 (RJ)、花粉或幼虫。在大鼠眨眼抑制的干眼模型中口服每种蜜蜂产品后，评估了泪液分泌能力。测量泪液分泌、LG ATP 含量和 LG 线粒体水平的变化。 RJ最大限度地恢复了泪液分泌能力并降低了LG ATP含量和线粒体水平。蜂王浆可通过控制 LG 的泪液分泌能力来预防干眼症。
Tears are secreted from the lacrimal gland (LG), a dysfunction in which induces dry eye, resulting in ocular discomfort and visual impairment. Honey bee products are used as a nutritional source in daily life and medicine; however, little is known about their effects on dry eye. The aim of the present study was to investigate the effects of honey bee products on tear secretion capacity in dry eye. We selected raw honey, propolis, royal jelly (RJ), pollen, or larva from commercially available honey bee products. Tear secretion capacity was evaluated following the oral administration of each honey bee product in a rat blink-suppressed dry eye model. Changes in tear secretion, LG ATP content, and LG mitochondrial levels were measured. RJ restored the tear secretion capacity and decrease in LG ATP content and mitochondrial levels to the largest extent. Royal jelly can be used as a preventative intervention for dry eye by managing tear secretion capacity in the LG.
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影响因子：
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作者：
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通讯作者：
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