Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases.
Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases.
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DOI：
10.1016/j.preteyeres.2009.04.003
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发表时间：
2009-05
影响因子：
17.8
通讯作者：
Dartt, Darlene A.
中科院分区：
文献类型：
--
作者：
Dartt, Darlene A.
关键词：
泪腺是泪膜的水层的主要贡献者，其由水、电解质和蛋白质组成。该层的量和组成对于角膜和结膜（眼表面）细胞的健康、维持和保护至关重要。泪液电解质浓度的微小变化与干眼综合征有关。虽然泪腺分泌水、电解质和蛋白质的机制不同，但三者都受到严格的神经控制。这允许快速响应以满足眼表面细胞响应于环境条件的需要。神经反应包括激活角膜和结膜中的传入感觉神经以刺激支配泪腺的传出副交感神经和交感神经。神经递质从刺激的副交感神经和交感神经释放，引起水、电解质和蛋白质从泪腺分泌到眼表面上。本文综述了泪腺分泌的神经调节在正常和干眼条件下。
The lacrimal gland is the major contributor to the aqueous layer of the tear film which consists of water, electrolytes and proteins. The amount and composition of this layer is critical for the health, maintenance, and protection of the cells of the cornea and conjunctiva (the ocular surface). Small changes in the concentration of tear electrolytes have been correlated with dry eye syndrome. While the mechanisms of secretion of water, electrolytes and proteins from the lacrimal gland differ, all three are under tight neural control. This allows for a rapid response to meet the needs of the cells of the ocular surface in response to environmental conditions. The neural response consists of the activation of the afferent sensory nerves in the cornea and conjunctiva to stimulate efferent parasympathetic and sympathetic nerves that innervate the lacrimal gland. Neurotransmitters are released from the stimulated parasympathetic and sympathetic nerves that cause secretion of water, electrolytes, and proteins from the lacrimal gland and onto the ocular surface. This review focuses on the neural regulation of lacrimal gland secretion under normal and dry eye conditions.
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影响因子：
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Belmonte, Carlos
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Belmonte, Carlos
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作者：
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