Regulatory role of long non coding RNAs (lncRNAs) in neurological disorders: From novel biomarkers to promising therapeutic strategies.
Regulatory role of long non coding RNAs (lncRNAs) in neurological disorders: From novel biomarkers to promising therapeutic strategies.
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长链非编码RNA（lncRNA）在神经系统疾病中的调节作用：从新型生物标志物到有前途的治疗策略
DOI：
10.1016/j.ajps.2021.02.006
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发表时间：
2021-09
影响因子：
10.2
通讯作者：
Dey A
中科院分区：
文献类型：
--
作者：
Bhattacharyya N;Pandey V;Bhattacharyya M;Dey A
长链非编码RNA（lncRNA）是非蛋白质或低蛋白质编码的转录物。lncRNA含有超过200个核苷酸。LncRNA与包括神经系统疾病在内的疾病致病性相关。LncRNA通过诱饵、支架、miRNA螯合剂、组蛋白修饰剂和转录干扰介导发病机制。LncRNA可以作为治疗方面的新型生物标志物。长链非编码RNA（longnoncodingRNA，lncRNA）是一类含有200多个核苷酸的非蛋白质或低蛋白质编码转录物。它们代表了细胞转录输出的很大一部分，表现出功能属性，即组织特异性表达，决定细胞命运，受控表达，RNA加工和编辑，剂量补偿，基因组印记，保守的进化性状等。这些长的非编码变体与各种疾病的致病性密切相关，包括阿尔茨海默病，精神分裂症，亨廷顿氏病、帕金森氏病等。神经系统疾病很普遍，了解其潜在机制至关重要。lncRNA通过诱饵、支架、mi-RNA螯合剂、组蛋白修饰剂等多种机制和转录干扰参与了肿瘤的发病过程。详细了解lncRNA的作用可以帮助进一步将其用作治疗方面的新型生物标志物。在这里，在这篇综述中，我们讨论了lncRNA在8种神经系统疾病和精神疾病中的调节和功能作用，以及它们的作用机制。有了这些，我们试图建立他们的作用，作为潜在的标志物和可行的诊断工具，在这些疾病。
Long non coding RNAs (lncRNAs) are non-protein or low-protein coding transcripts. LncRNAs contain more than 200 nucleotides. LncRNAs are associated with disease pathogenicity including the neurological disorders. LncRNAs mediate pathogenesis by decoy, scaffold, mi-RNA sequestrator, histone modifiers and in transcriptional interference. LncRNAs can serve as novel biomarkers for therapeutic aspects. Long non coding RNAs (lncRNAs) are non-protein or low-protein coding transcripts that contain more than 200 nucleotides. They representing a large share of the cell's transcriptional output, demonstrate functional attributes viz. tissue-specific expression, determination of cell fate, controlled expression, RNA processing and editing, dosage compensation, genomic imprinting, conserved evolutionary traits etc. These long non coding variants are well associated with pathogenicity of various diseases including the neurological disorders like Alzheimer's disease, schizophrenia, Huntington's disease, Parkinson's disease etc. Neurological disorders are widespread and there knowing the underlying mechanisms become crucial. The lncRNAs take part in the pathogenesis by a plethora of mechanisms like decoy, scaffold, mi-RNA sequestrator, histone modifiers and in transcriptional interference. Detailed knowledge of the role of lncRNAs can help to use them further as novel biomarkers for therapeutic aspects. Here, in this review we discuss regulation and functional roles of lncRNAs in eight neurological diseases and psychiatric disorders, and the mechanisms by which they act. With these, we try to establish their roles as potential markers and viable diagnostic tools in these disorders.
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