Impact of epidermal desquamation on tissue stores of iron.
Impact of epidermal desquamation on tissue stores of iron.
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DOI：
10.1016/j.jdermsci.2012.04.003
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发表时间：
2012-07
影响因子：
4.6
通讯作者：
Zhou J
中科院分区：
文献类型：
--
作者：
Milstone LM;Hu RH;Dziura JD;Zhou J
尽管每天有数十亿角质细胞从人体皮肤脱落，但50年前的代谢研究得出结论，角质细胞脱落对人体全身蛋白质或铁状态没有可测量的影响。在表皮中引入改变皮肤中铁代谢的局部遗传变化后，测量内脏器官的铁含量。在三种不同的在表皮中表达转基因的小鼠模型中，在断奶后7周测量来自动物组的组织和血液中的铁：其中HPV 16 E7基因引起表皮更新3倍增加的过度增殖模型;其中转铁蛋白受体的过度表达引起表皮中铁3-4倍增加的表皮铁库模型;系统性血色素沉着症敲除模型已与表皮铁汇模型交叉。在表皮中具有铁汇转基因的血色素沉着病模型中，血清和肝脏和肾脏中的非血红素铁在统计学上显著减少。在所有模型中，肾脏中非血红素铁的减少具有统计学意义。表皮中铁代谢的局部变化可对全身铁代谢产生可测量的影响。这意味着，表皮内稳态的破坏可能会影响微量营养素的全身水平，循环毒素可能会通过将其隔离在表皮中来修复。
Although several billion corneocytes are shed from human skin daily, metabolic studies from 50 years ago led to the conclusion that corneocyte desquamation had no measurable impact on systemic protein or iron status in humans. To measure iron content of internal organs after introducing local genetic changes in epidermis that alter iron metabolism in skin. Iron was measured in tissues and blood from groups of animals 7 weeks after weaning in three different mouse models expressing a transgene in epidermis: a hyperproliferation model in which the HPV16 E7 gene causes a 3-fold increase in epidermal turnover; an epidermal iron sink model in which overexpression of the transferrin receptor causes a 3–4 fold increase of iron in epidermis; a systemic hemochromatosis knockout model that has been crossed with the epidermal iron sink model. In the hemochromatosis model with the iron sink transgene in epidermis, there was a statistically significant reduction in non-heme iron in serum and in the liver and kidney. In all models there was a statistically significant reduction in non-heme iron in the kidney. Local changes in iron metabolism in epidermis can have a measurable impact on systemic iron metabolism. By implication, disruptions in epidermal homeostasis might affect systemic levels of trace nutrients, and circulating toxins might be remediated by sequestering them in epidermis.
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影响因子：
3.9
作者：
Hahn, Paul;Song, Ying;Dunaief, Joshua L.
通讯作者：
Dunaief, Joshua L.
影响因子：
--
作者：
MARKS, J;SHUSTER, S
通讯作者：
SHUSTER, S
影响因子：
6.5
作者：
Milstone, Leonard M.;Adams, Brian D.;Shofner, Joshua
通讯作者：
Shofner, Joshua
DOI：
10.3109/00365517609054495
发表时间：
1976-01-01
影响因子：
2.1
作者：
MOLIN, L;WESTER, PO
通讯作者：
WESTER, PO
影响因子：
6.5
作者：
Adams, BD;Lazova, R;Milstone, LM
通讯作者：
Milstone, LM