Gut microbiota, NLR proteins, and intestinal homeostasis.
Gut microbiota, NLR proteins, and intestinal homeostasis.
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肠道微生物群、NLR 蛋白和肠道稳态。
DOI：
10.1084/jem.20181832
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发表时间：
2020-10-05
期刊：
影响因子：
--
通讯作者：
Ting JPY
中科院分区：
文献类型：
--
作者：
Guo H;Gibson SA;Ting JPY
宿主和肠道菌群之间的广泛串扰有助于肠道上皮和免疫系统的发育和成熟。本文详细介绍了核苷酸结合结构域富含亮氨酸重复序列的蛋白质（NLR或NOD样受体）之间的相互作用，信号宿主微生物群的稳态。胃肠道内有一个高度复杂的微生物群落，称为肠道微生物群。随着越来越多的证据表明肠道微生物群的不平衡在多种疾病的发病机制中起着重要作用，宿主免疫系统和肠道微生物群之间的相互作用现在正在引起人们的兴趣。核苷酸结合和富含亮氨酸重复序列的受体（NLR）包括大量先天免疫传感器和受体，其介导Caspase-1的活化和随后成熟白细胞介素-1 β和白细胞介素-18的释放。已经发现几个家族成员抑制而不是激活炎性细胞因子和免疫信号传导。NLR家族成员是病原体识别、宿主免疫和炎症的中心调节因子，在人类疾病中具有极其重要的意义。在这篇综述中，我们重点关注NLR在控制和塑造微生物群中所发挥的潜在作用，并讨论将肠道微生物群与NLR相互连接的功能轴如何影响结肠炎，炎症性肠病和结直肠癌的调节。
An extensive crosstalk between host and intestinal microbiota contributes to the development and maturation of intestinal epithelium and immune system. This review details the interplay between nucleotide-binding domain leucine-rich repeat containing proteins (NLR, or NOD-like receptors) signaling to host-microbiota homeostasis. The gastrointestinal tract harbors a highly complex microbial community, which is referred to as gut microbiota. With increasing evidence suggesting that the imbalance of gut microbiota plays a significant role in the pathogenesis of multiple diseases, interactions between the host immune system and the gut microbiota are now attracting emerging interest. Nucleotide-binding and leucine-rich repeat–containing receptors (NLRs) encompass a large number of innate immune sensors and receptors, which mediate the activation of Caspase-1 and the subsequent release of mature interleukin-1β and interleukin-18. Several family members have been found to restrain rather than activate inflammatory cytokines and immune signaling. NLR family members are central regulators of pathogen recognition, host immunity, and inflammation with utmost importance in human diseases. In this review, we focus on the potential roles played by NLRs in controlling and shaping the microbiota community and discuss how the functional axes interconnecting gut microbiota with NLRs impact the modulation of colitis, inflammatory bowel diseases, and colorectal cancer.
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DOI：
10.1038/nrmicro3552
发表时间：
2016-01
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
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影响因子：
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