Tumor Necrosis Factor-α Inhibits Surfactant Protein C Gene Transcription (*)
Tumor Necrosis Factor-α Inhibits Surfactant Protein C Gene Transcription (*)
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肿瘤坏死因子-α 抑制表面活性剂蛋白 C 基因转录 (*)
DOI：
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发表时间：
1995
影响因子：
4.8
通讯作者：
J. Whitsett
中科院分区：
文献类型：
--
作者：
C. Bachurski;G. Pryhuber;S. Glasser;S. Kelly;J. Whitsett
Pulmonary surfactant protein C (SP-C) is a 3.7-kDa, hydrophobic peptide secreted by alveolar type II epithelial cells. SP-C enhances surface tension lowering activity of surfactant phospholipids that is critical to the maintenance of alveolar volume at end expiration. The proinflammatory cytokine, tumor necrosis factor α (TNF-α), decreased SP-C mRNA within 24 h of intratracheal administration to mice. In vitro, TNF-α decreased SP-C mRNA in a time- and dose-dependent manner, reducing the steady state levels of SP-C mRNA by 3-5-fold. In contrast, TNF-α induced intercellular adhesion molecule-1 expression in both mouse lung and murine lung epithelial cell lines. Nuclear run-on analysis demonstrated that transcription of both the endogenous SP-C gene and a human SP-C promoter-driven transgene was inhibited by TNF-α. TNF-α decreased mouse SP-C-chloramphenicol acetyltransferase mRNA in stably transfected murine lung epithelial cells. Deletion analysis of the SP-C promoter region demonstrated that TNF-α inhibited gene expression in constructs containing 320 base pairs 5′ from the start of transcription of the mouse SP-C gene. Inhibition of surfactant protein C gene transcription by TNF-α may contribute to the abnormalities of surfactant homeostasis associated with pulmonary injury and infection.
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DOI：
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发表时间：
1991
期刊：
The American journal of pathology
影响因子：
--
作者：
Ulich,TR;Watson,LR;Yin,SM;Guo,KZ;Wang,P;Thang,H;delCastillo,J
通讯作者：
delCastillo,J
DOI：
10.1073/pnas.90.23.11029
发表时间：
1993-12-01
影响因子：
11.1
作者：
WIKENHEISER, KA;VORBROKER, DK;WHITSETT, JA
通讯作者：
WHITSETT, JA
影响因子：
56.9
作者：
DRANOFF, G;CRAWFORD, AD;MULLIGAN, RC
通讯作者：
MULLIGAN, RC
佛波酯抑制表面活性蛋白 SP-A 和 SP-B 的表达。
DOI：
--
发表时间：
1990
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Pryhuber,GS;O'Reilly,MA;Clark,JC;Hull,WM;Fink,I;Whitsett,JA
通讯作者：
Whitsett,JA
小鼠肺表面活性蛋白SP-C基因的结构和表达。
DOI：
--
发表时间：
1990
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Glasser,SW;Korfhagen,TR;Bruno,MD;Dey,C;Whitsett,JA
通讯作者：
Whitsett,JA