Patency of the preterm fetal ductus arteriosus is regulated by endothelial nitric oxide synthase and is independent of vasa vasorum in the mouse.
Patency of the preterm fetal ductus arteriosus is regulated by endothelial nitric oxide synthase and is independent of vasa vasorum in the mouse.
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早产胎儿动脉导管的通畅是由内皮一氧化氮合酶调节的，并且与小鼠的血管滋养管无关。
DOI：
10.1152/ajpregu.00049.2004
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Reese,Jeff
中科院分区：
文献类型：
--
作者：
Richard,Charissa;Gao,Ju;LaFleur,Bonnie;Christman,BrianW;Anderson,Judy;Brown,Naoko;Reese,Jeff
Patency of the fetal ductus arteriosus (DA) is maintained in an environment of low relative oxygen tension and a preponderance of vasodilating forces. In addition to prostaglandins, nitric oxide (NO), a potent vasodilator in the pulmonary and systemic vasculatures, has been implicated in regulation of the fetal DA. To further define the contribution of NO to DA patency, the expression and function of NO synthase (NOS) isoforms were examined in the mouse DA ondays 17–19of pregnancy and after birth. Our results show that endothelial NOS (eNOS) is the predominant isoform expressed in the mouse DA and is localized in the DA endothelium by in situ hybridization. Despite rapid constriction of the DA after birth, eNOS expression levels were unchanged throughout the fetal and postnatal period. Pharmacological inhibition of prostaglandin vs. NO synthesis in vivo showed that the preterm fetal DA onday 16is more sensitive to NOS inhibition than the mature fetal DA onday 19, whereas prostaglandin inhibition results in marked DA constriction onday 19but minimal effects on theday 16DA. Combined prostaglandin and NO inhibition caused additional DA constriction onday 16. The contribution of vasa vasorum to DA regulation was also examined. Immunoreactive platelet endothelial cell adhesion molecule and lacZ tagged FLK1 localized to DA endothelial cells but revealed the absence of vasa vasorum within the DA wall. Similarly, there was no evidence of vasa vasorum by vascular casting. These studies indicate that eNOS is the primary source of NO in the mouse DA and that vasomotor tone of the preterm fetal mouse DA is regulated by eNOS-derived NO and is potentiated by prostaglandins. In contrast to other species, mechanisms for DA patency and closure appear to be independent of any contribution of the vasa vasorum.
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DOI：
10.1083/jcb.107.5.1853
发表时间：
1988-11
期刊：
The Journal of cell biology
影响因子：
--
作者：
Streeter PR;Rouse BT;Butcher EC
通讯作者：
Butcher EC
影响因子：
56.9
作者：
BEVILACQUA, MP;STENGELIN, S;SEED, B
通讯作者：
SEED, B
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DOI：
--
发表时间：
1989
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Johnston,GI;Kurosky,A;McEver,RP
通讯作者：
McEver,RP
LFA-1 在归巢过程中淋巴细胞与高内皮细胞相互作用中发挥辅助作用的证据。
DOI：
--
发表时间：
1988
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Hamann,A;Jablonski-Westrich,D;Duijvestijn,A;Butcher,EC;Baisch,H;Harder,R;Thiele,HG
通讯作者：
Thiele,HG
静脉注射唾液酸酶可使高内皮微静脉上淋巴细胞的附着位点失活。
DOI：
--
发表时间：
1989
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Rosen,SD;Chi,SI;True,DD;Singer,MS;Yednock,TA
通讯作者：
Yednock,TA