Emerging single-cell tools are primed to reveal functional and molecular heterogeneity in malignant hematopoietic stem cells.

Emerging single-cell tools are primed to reveal functional and molecular heterogeneity in malignant hematopoietic stem cells.
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新兴的单细胞工具有望揭示恶性造血干细胞的功能和分子异质性。

DOI:
10.1097/moh.0000000000000512
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发表时间:
2019
影响因子:
3.2
通讯作者:
Shepherd MS
Shepherd MS
中科院分区:
医学3区
文献类型:
--
作者:
Shepherd MS

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尽管存在单细胞基因表达谱工具,但发表的出版物相对较少。在这里,我们回顾了近年来的这些研究,特别关注那些在恶性干细胞和祖细胞中进行单细胞测量的研究。我们预计这只是冰山一角,预计未来 2-3 年将产生有助于更广泛地了解恶性 HSC 的数据集。
Despite the existence of single-cell gene expression profiling tools, relatively few publications have emerged. Here, we review these studies from recent years with a specific focus on those undertaking single-cell measurements in malignant stem and progenitor cells. We anticipate this to be the tip of the iceberg, expecting the next 2–3 years to produce datasets that will facilitate a much broader understanding of malignant HSCs.
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