Intravoxel incoherent motion diffusion-weighted imaging and shear wave elastography for evaluating peritumoral liver fibrosis after transarterial chemoembolization in a VX2 rabbit liver tumor model.
Intravoxel incoherent motion diffusion-weighted imaging and shear wave elastography for evaluating peritumoral liver fibrosis after transarterial chemoembolization in a VX2 rabbit liver tumor model.
复制标题
体素内不相干运动扩散加权成像和剪切波弹性成像评估 VX2 兔肝肿瘤模型经动脉化疗栓塞术后瘤周肝纤维化
DOI：
10.3389/fphys.2022.893925
复制
发表时间：
2022
影响因子：
4
通讯作者：
Zhang, Shuai
中科院分区：
文献类型：
--
作者：
Cheng, Zhimei;Yang, Qin;He, Huizhou;Li, Ran;Li, Xueying;Jiang, Hongyu;Zhao, Xuya;Li, Junxiang;Wang, Lizhou;Zhou, Shi;Zhang, Shuai
关键词：
在这项研究中，我们试图评估经动脉化疗栓塞（TACE）后的兔VX 2肝肿瘤模型中的瘤周纤维化的变化，使用体素内非相干运动扩散加权成像（IVIM DWI）和超声剪切波弹性成像（SWE）。共20只家兔接受了肝左叶中VX 2肿瘤组织的植入。将家兔随机分为实验组（n = 10）和对照组（n = 10）。实验组在植入后2-3周通过微导管给予碘油和吡拉托品乳剂治疗;对照组给予无菌水治疗。与对照组相比，实验组肝组织的真扩散系数（D）和假扩散系数（D*）值均显著降低（P均< 0.05），肝硬度值（LSV）（10.58 ± 0.89 kPa）显著升高（7.65 ± 0.86 kPa; P < 0.001）。对照组中基于METAVIR评分的肝纤维化中位分期为1（1，1），实验组中为2（2，3）（Z = 4.15，p < 0.001）。D、D* 和LSV在肝纤维化评估中与病理染色显著相关（分别为r =-0.54，p = 0.015; r =-0.50，p = 0.025; r = 0.91，p < 0.001）。这些数据表明，在兔VX 2肝肿瘤模型中，TACE加重了肝损伤和肝纤维化，特别是肿瘤周围。IVIM DWI和SWE可用于评价肝纤维化程度。
In this study, we sought to evaluate changes in peritumoral fibrosis after transarterial chemoembolization (TACE) in a rabbit VX2 liver tumor model using intravoxel incoherent motion diffusion-weighted imaging (IVIM DWI) and ultrasound shear wave elastography (SWE). A total of 20 rabbits underwent implantation of VX2 tumor tissues in the left lobe of the liver. The rabbits were randomly divided into an experimental group (n = 10) or a control group (n = 10). Those in the experimental group were treated with an emulsion of lipiodol and pirarubicin through a microcatheter 2–3 weeks after implantation; those in the control group were treated with sterile water. Compared with the control group, the true diffusion coefficient (D) and pseudodiffusion coefficient (D*) values in liver tissues were significantly lower (p < 0.05 for all) and liver stiffness values (LSV) (10.58 ± 0.89 kPa) were higher in the experimental group (7.65 ± 0.86 kPa; p < 0.001). The median stage of liver fibrosis based on METAVIR scores was 1 (1,1) in the control group and 2 (2,3) in the experimental group (Z = 4.15, p < 0.001). D, D*, and LSV were significantly correlated with pathologic staining in the assessment of liver fibrosis (r = −0.54 p = 0.015; r = −0.50, p = 0.025; r = 0.91, p < 0.001; respectively). These data suggest that TACE aggravates liver injury and liver fibrosis, especially surrounding the tumor, in a rabbit VX2 liver tumor model. IVIM DWI and SWE can be used to evaluate the change in liver fibrosis.
登录
查看更多内容
影响因子：
2.4
作者：
Chen, JH;Lin, YC;Han, KW
通讯作者：
Han, KW
影响因子：
2.5
作者：
Barry, Brian;Buch, Karen;Anderson, Stephan W.
通讯作者：
Anderson, Stephan W.
影响因子：
4.1
作者：
Chen L;Liu ZX;Bi QC;Zhao J;Liang QR;Tang Q
通讯作者：
Tang Q
影响因子：
3.3
作者：
Chen, Shuochun;Jiang, Tian'an
通讯作者：
Jiang, Tian'an
肝纤维化的无创评估：MR 弹性成像与瞬时弹性成像和体素内不相干运动扩散加权 MRI 的比较
影响因子：
2.4
作者：
Fu, Fangfang;Li, Xiaodong;Wang, Meiyun
通讯作者：
Wang, Meiyun