Characterization of KIF11 as a novel prognostic biomarker and therapeutic target for oral cancer.
Characterization of KIF11 as a novel prognostic biomarker and therapeutic target for oral cancer.
复制标题
DOI：
10.3892/ijo.2017.4181
复制
发表时间：
2018-01
影响因子：
5.2
通讯作者：
Daigo Y
中科院分区：
文献类型：
--
作者：
Daigo K;Takano A;Thang PM;Yoshitake Y;Shinohara M;Tohnai I;Murakami Y;Maegawa J;Daigo Y
口腔癌死亡率高，在世界范围内发病率呈逐渐上升趋势。由于标准治疗的有效性仍然有限，因此迫切需要开发新的治疗策略。驱动蛋白家族成员11（KIF 11）是在细胞分裂中建立双极纺锤体所需的马达蛋白。KIF 11在口腔癌中的作用尚不清楚。因此，本研究旨在评估KIF 11在口腔癌中的作用，并评估其作为治疗口腔癌的预后生物标志物和治疗靶点的作用。免疫组化结果显示，KIF 11在99例口腔癌组织中有64例（64.6%）表达，而在正常口腔上皮中无表达。KIF 11强表达与口腔癌患者的不良预后显著相关（P=0.034），多因素分析证实其独立的预后价值。此外，通过将siRNA转染到口腔癌细胞中或用KIF 11抑制剂处理细胞来抑制KIF 11表达显著抑制了细胞增殖，这可能是通过G2/M期阻滞和随后的凋亡诱导。这些结果表明，KIF 11可能是口腔癌的潜在预后生物标志物和治疗靶点。
Oral cancer has a high mortality rate, and its incidence is increasing gradually worldwide. As the effectiveness of standard treatments is still limited, the development of new therapeutic strategies is eagerly awaited. Kinesin family member 11 (KIF11) is a motor protein required for establishing a bipolar spindle in cell division. The role of KIF11 in oral cancer is unclear. Therefore, the present study aimed to assess the role of KIF11 in oral cancer and evaluate its role as a prognostic biomarker and therapeutic target for treating oral cancer. Immunohistochemical analysis demonstrated that KIF11 was expressed in 64 of 99 (64.6%) oral cancer tissues but not in healthy oral epithelia. Strong KIF11 expression was significantly associated with poor prognosis among oral cancer patients (P=0.034), and multivariate analysis confirmed its independent prognostic value. In addition, inhibition of KIF11 expression by transfection of siRNAs into oral cancer cells or treatment of cells with a KIF11 inhibitor significantly suppressed cell proliferation, probably through G2/M arrest and subsequent induction of apoptosis. These results suggest that KIF11 could be a potential prognostic biomarker and therapeutic target for oral cancer.
登录
查看更多内容
影响因子：
6.6
作者：
Ma, Hoi Tang;Erdal, Sergio;Poon, Randy Y. C.
通讯作者：
Poon, Randy Y. C.
影响因子：
11.2
作者：
Kato, T;Daigo, Y;Nakamura, Y
通讯作者：
Nakamura, Y
影响因子：
8
作者：
Kikuchi, T;Daigo, Y;Nakamura, Y
通讯作者：
Nakamura, Y
影响因子：
11.2
作者：
Hayama, Satoshi;Daigo, Yataro;Nakamura, Yusuke
通讯作者：
Nakamura, Yusuke
影响因子：
158.5
作者：
Bernier, J;Domenge, C;van Glabbeke, M
通讯作者：
van Glabbeke, M