Validation of DTI tractography-based measures of primary motor area connectivity in the squirrel monkey brain.
Validation of DTI tractography-based measures of primary motor area connectivity in the squirrel monkey brain.
复制标题
DOI：
10.1371/journal.pone.0075065
复制
发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Anderson AW
中科院分区：
文献类型：
--
作者：
Gao Y;Choe AS;Stepniewska I;Li X;Avison MJ;Anderson AW
扩散张量成像（DTI）纤维束成像提供了大脑结构皮质-皮质连接性的非侵入性测量。然而，DTI纤维束成像为基础的措施和组织学的“地面真相”之间的协议尚未量化。在这项研究中，我们重建了3D密度分布图（DDM）的纤维标记的解剖示踪剂，生物素葡聚糖胺（BDA），以及DTI tractography衍生的流线连接初级运动（M1）皮层的其他皮质区域的松鼠猴脑。我们评估了M1-皮质连接之间的协议，标记在脑组织和DTI流线的区域和体素的基础上的纤维。我们发现DTI纤维束成像能够提供与神经解剖学连接相当的区域间连接，但测量区域内体素到体素的变化不太可靠。
Diffusion tensor imaging (DTI) tractography provides noninvasive measures of structural cortico-cortical connectivity of the brain. However, the agreement between DTI-tractography-based measures and histological ‘ground truth’ has not been quantified. In this study, we reconstructed the 3D density distribution maps (DDM) of fibers labeled with an anatomical tracer, biotinylated dextran amine (BDA), as well as DTI tractography-derived streamlines connecting the primary motor (M1) cortex to other cortical regions in the squirrel monkey brain. We evaluated the agreement in M1-cortical connectivity between the fibers labeled in the brain tissue and DTI streamlines on a regional and voxel-by-voxel basis. We found that DTI tractography is capable of providing inter-regional connectivity comparable to the neuroanatomical connectivity, but is less reliable measuring voxel-to-voxel variations within regions.
登录
查看更多内容
影响因子：
5.7
作者：
Hagmann, P;Thiran, JP;Meuli, R
通讯作者：
Meuli, R
影响因子：
3.7
作者：
Hagmann, Patric;Kurant, Maciej;Gigandet, Xavier;Thiran, Patrick;Wedeen, Van J.;Meuli, Reto;Thiran, Jean-Philippe
通讯作者：
Thiran, Jean-Philippe
影响因子：
3.3
作者：
Anderson, AW
通讯作者：
Anderson, AW
影响因子：
3.3
作者：
Alexander, AL;Hasan, KM;Parker, DL
通讯作者：
Parker, DL
影响因子：
6.1
作者：
Jiang, HY;van Zijl, PCM;Mori, S
通讯作者：
Mori, S