Mapping human whole-brain structural networks with diffusion MRI.

Mapping human whole-brain structural networks with diffusion MRI.
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DOI:
10.1371/journal.pone.0000597
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发表时间:
2007-07-04
期刊:
影响因子:
3.7
通讯作者:
Thiran, Jean-Philippe
Thiran, Jean-Philippe
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Hagmann, Patric;Kurant, Maciej;Gigandet, Xavier;Thiran, Patrick;Wedeen, Van J.;Meuli, Reto;Thiran, Jean-Philippe

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理解由神经元形成的大规模结构网络是系统神经科学的一个重大挑战。因此,覆盖整个大脑的详细连接图将具有巨大价值。基于扩散MRI,我们提出了一种有效的方法来生成活的或死的、人类或动物大脑的大型、全面且个体的白色物质连接数据集。这种非侵入性工具使我们能够研究整个大脑的基本和潜在的复杂网络特性。对于两个人类受试者,我们发现他们的个人大脑网络具有指数节点度分布,他们的全球组织是一个小世界的形式。
Understanding the large-scale structural network formed by neurons is a major challenge in system neuroscience. A detailed connectivity map covering the entire brain would therefore be of great value. Based on diffusion MRI, we propose an efficient methodology to generate large, comprehensive and individual white matter connectional datasets of the living or dead, human or animal brain. This non-invasive tool enables us to study the basic and potentially complex network properties of the entire brain. For two human subjects we find that their individual brain networks have an exponential node degree distribution and that their global organization is in the form of a small world.
DOI: 10.1093/cercor/1.1.1
发表时间: 1991-01-01
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