The microRNAs as potential biomarkers for predicting the onset of aflatoxin exposure in human beings: a review.
The microRNAs as potential biomarkers for predicting the onset of aflatoxin exposure in human beings: a review.
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DOI：
10.3389/fmicb.2014.00102
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发表时间：
2014
影响因子：
5.2
通讯作者：
Arenas-Huertero F
中科院分区：
文献类型：
--
作者：
Valencia-Quintana R;Sánchez-Alarcón J;Tenorio-Arvide MG;Deng Y;Montiel-González JM;Gómez-Arroyo S;Villalobos-Pietrini R;Cortés-Eslava J;Flores-Márquez AR;Arenas-Huertero F
确定黄曲霉毒素为人类致癌物，激发了广泛的研究工作，并持续到现在，以评估人类食品供应污染造成的潜在健康危害，并尽量减少接触。使用毒理学研究在机制上支持的生物标志物将是确定环境因子健康影响发展阶段的重要工具。miRNAs是一类调控转录后基因表达的小分子非编码mRNAs。此外，它们是细胞对各种化学试剂反应的分子标记物。越来越多的证据表明，环境化学物质可以诱导miRNA表达的变化。miRNA是良好的生物标志物，因为它们定义明确，化学均匀，限于可管理的物种数量，并且在细胞和循环中稳定。miRNA已被用作HCC和其他肿瘤的血清学标志物。不同miRNA的表达模式可以区分HCC-肝炎病毒相关的、HCC衍生的和与它们中的任一个无关的HCC。本综述的主要目的是寻找未报道的与其他原因相关的HCC中的miRNAs，以便它们可以用作暴露于黄曲霉毒素的人群的特异性分子生物标志物和作为暴露、损伤/存在HCC的早期标志物。直到今天，作为黄曲霉毒素暴露标记物的特异性miRNA及其可靠性目前还缺乏。基于其阐明的作用机制，可以通过暴露于黄曲霉毒素而充当HCC的可能标志物的潜在miRNA是miR-27 a、miR-27 b、miR-122、miR-148、miR-155、miR-192、miR-214、miR-221、miR-429和miR-500。所有这些miRNAs的未来验证将需要评估其预后意义，并确认它们与黄曲霉毒素暴露诱导HCC的关系。
The identification of aflatoxins as human carcinogens has stimulated extensive research efforts, which continue to the present, to assess potential health hazards resulting from contamination of the human food supply and to minimize exposure. The use of biomarkers that are mechanistically supported by toxicological studies will be important tools for identifying stages in the progression of development of the health effects of environmental agents. miRNAs are small non-coding mRNAs that regulate post-transcriptional gene expression. Also, they are molecular markers of cellular responses to various chemical agents. Growing evidence has demonstrated that environmental chemicals can induce changes in miRNA expression. miRNAs are good biomarkers because they are well defined, chemically uniform, restricted to a manageable number of species, and stable in cells and in the circulation. miRNAs have been used as serological markers of HCC and other tumors. The expression patterns of different miRNAs can distinguish among HCC-hepatitis viruses related, HCC cirrhosis-derivate, and HCC unrelated to either of them. The main objective of this review is to find unreported miRNAs in HCC related to other causes, so that they can be used as specific molecular biomarkers in populations exposed to aflatoxins and as early markers of exposure, damage/presence of HCC. Until today specific miRNAs as markers for aflatoxins-exposure and their reliability are currently lacking. Based on their elucidated mechanisms of action, potential miRNAs that could serve as possible markers of HCC by exposure to aflatoxins are miR-27a, miR-27b, miR-122, miR-148, miR-155, miR-192, miR-214, miR-221, miR-429, and miR-500. Future validation for all of these miRNAs will be needed to assess their prognostic significance and confirm their relationship with the induction of HCC due to aflatoxin exposure.
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